Speech and gait abnormalities in motor subtypes of de-novo Parkinson's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F23%3A00367040" target="_blank" >RIV/68407700:21230/23:00367040 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21460/23:00367040 RIV/00216208:11110/23:10458845 RIV/00216208:11310/23:10458845 RIV/00064165:_____/23:10458845

Výsledek na webu

<a href="https://doi.org/10.1111/cns.14158" target="_blank" >https://doi.org/10.1111/cns.14158</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cns.14158" target="_blank" >10.1111/cns.14158</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Speech and gait abnormalities in motor subtypes of de-novo Parkinson's disease

Popis výsledku v původním jazyce

AimTo investigate the presence and relationship of temporal speech and gait parameters in patients with postural instability/gait disorder (PIGD) and tremor-dominant (TD) motor subtypes of Parkinson's disease (PD). MethodsSpeech samples and instrumented walkway system assessments were acquired from a total of 60 de-novo PD patients (40 in TD and 20 in PIGD subtype) and 40 matched healthy controls. Objective acoustic vocal assessment of seven distinct speech timing dimensions was related to instrumental gait measures including velocity, cadence, and stride length. ResultsCompared to controls, PIGD subtype showed greater consonant timing abnormalities by prolonged voice onset time (VOT) while also shorter stride length during both normal walking and dual task, while decreased velocity and cadence only during dual task. Speaking rate was faster in PIGD than TD subtype. In PIGD subtype, prolonged VOT correlated with slower gait velocity (r = -0.56, p = 0.01) and shorter stride length (r = -0.59, p = 0.008) during normal walking, whereas relationships were also found between decreased cadence in dual task and irregular alternating motion rates (r = -0.48, p = 0.04) and prolonged pauses (r = -0.50, p = 0.03). No correlation between speech and gait was detected in TD subtype. ConclusionOur findings suggest that speech and gait rhythm disorder share similar underlying pathomechanisms specific for PIGD subtype.

Název v anglickém jazyce

Speech and gait abnormalities in motor subtypes of de-novo Parkinson's disease

Popis výsledku anglicky

AimTo investigate the presence and relationship of temporal speech and gait parameters in patients with postural instability/gait disorder (PIGD) and tremor-dominant (TD) motor subtypes of Parkinson's disease (PD). MethodsSpeech samples and instrumented walkway system assessments were acquired from a total of 60 de-novo PD patients (40 in TD and 20 in PIGD subtype) and 40 matched healthy controls. Objective acoustic vocal assessment of seven distinct speech timing dimensions was related to instrumental gait measures including velocity, cadence, and stride length. ResultsCompared to controls, PIGD subtype showed greater consonant timing abnormalities by prolonged voice onset time (VOT) while also shorter stride length during both normal walking and dual task, while decreased velocity and cadence only during dual task. Speaking rate was faster in PIGD than TD subtype. In PIGD subtype, prolonged VOT correlated with slower gait velocity (r = -0.56, p = 0.01) and shorter stride length (r = -0.59, p = 0.008) during normal walking, whereas relationships were also found between decreased cadence in dual task and irregular alternating motion rates (r = -0.48, p = 0.04) and prolonged pauses (r = -0.50, p = 0.03). No correlation between speech and gait was detected in TD subtype. ConclusionOur findings suggest that speech and gait rhythm disorder share similar underlying pathomechanisms specific for PIGD subtype.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CNS Neuroscience and Therapeutics

ISSN

1755-5930

e-ISSN

1755-5949

Svazek periodika

29

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

2101-2110

Kód UT WoS článku

000953661700001

EID výsledku v databázi Scopus

2-s2.0-85150882634