Thermodynamic Model of Bone Adaptation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F07%3A04137640" target="_blank" >RIV/68407700:21340/07:04137640 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Thermodynamic Model of Bone Adaptation

Popis výsledku v původním jazyce

The capacity of bone to adapt to functional mechanical requirements has been known for more than a century, and many theoretical and experimental models have been developed for bone remodelling. However, these models are still not able to sufficiently predict its behaviour. A thermodynamic model based on recent knowledge of biochemical control mechanisms is presented. Despite the complexity of the regulatory system of bone adaptation, the calculated results are in very good correlation with the experimental observations - the inner structure of bone can be elucidated, simulation of the influence of dynamic loading together with biochemical factors is carried out, e.g. the fundamental RANKL-RANK-OPG pathway, and a comparism between model prediction andx-ray pictures of human patients of the effect of bone adaptation to prosthesis insertion is done.

Název v anglickém jazyce

Thermodynamic Model of Bone Adaptation

Popis výsledku anglicky

The capacity of bone to adapt to functional mechanical requirements has been known for more than a century, and many theoretical and experimental models have been developed for bone remodelling. However, these models are still not able to sufficiently predict its behaviour. A thermodynamic model based on recent knowledge of biochemical control mechanisms is presented. Despite the complexity of the regulatory system of bone adaptation, the calculated results are in very good correlation with the experimental observations - the inner structure of bone can be elucidated, simulation of the influence of dynamic loading together with biochemical factors is carried out, e.g. the fundamental RANKL-RANK-OPG pathway, and a comparism between model prediction andx-ray pictures of human patients of the effect of bone adaptation to prosthesis insertion is done.

Druh

D - Stať ve sborníku

CEP obor

BA - Obecná matematika

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Doktorandské dny 2007

ISBN

978-80-01-03913-7

ISSN

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e-ISSN

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Počet stran výsledku

12

Strana od-do

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Název nakladatele

Česká technika - nakladatelství ČVUT

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

16. 11. 2007

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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