A coupled mechano-biochemical model for bone adaptation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F14%3A00211667" target="_blank" >RIV/68407700:21340/14:00211667 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388998:_____/14:00398880 RIV/49777513:23640/14:43924161

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs00285-013-0736-9" target="_blank" >http://link.springer.com/article/10.1007%2Fs00285-013-0736-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00285-013-0736-9" target="_blank" >10.1007/s00285-013-0736-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A coupled mechano-biochemical model for bone adaptation

Popis výsledku v původním jazyce

Bone remodelling is a fundamental biological process that controls bone microrepair, adaptation to environmental loads and calcium regulation among other important processes. It is not surprising that bone remodelling has been subject of intensive both experimental and theoretical research. In particular, many mathematical models have been developed in the last decades focusing in particular aspects of this complicated phenomenon where mechanics, biochemistry and cell processes strongly interact. In this paper, we present a new model that combines most of these essential aspects in bone remodelling with especial focus on the effect of the mechanical environment into the biochemical control of bone adaptation mainly associated to the well known RANKL-RANK-OPG pathway. The predicted results show a good correspondence with experimental and clinical findings. For example, our results indicate that trabecular bone is more severely affected both in disuse and disease than cortical bone what

Název v anglickém jazyce

A coupled mechano-biochemical model for bone adaptation

Popis výsledku anglicky

Bone remodelling is a fundamental biological process that controls bone microrepair, adaptation to environmental loads and calcium regulation among other important processes. It is not surprising that bone remodelling has been subject of intensive both experimental and theoretical research. In particular, many mathematical models have been developed in the last decades focusing in particular aspects of this complicated phenomenon where mechanics, biochemistry and cell processes strongly interact. In this paper, we present a new model that combines most of these essential aspects in bone remodelling with especial focus on the effect of the mechanical environment into the biochemical control of bone adaptation mainly associated to the well known RANKL-RANK-OPG pathway. The predicted results show a good correspondence with experimental and clinical findings. For example, our results indicate that trabecular bone is more severely affected both in disuse and disease than cortical bone what

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BJ - Termodynamika

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0088" target="_blank" >ED2.1.00/03.0088: Centrum nových technologií a materiálů (CENTEM)</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Mathematical Biology

ISSN

0303-6812

e-ISSN

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Svazek periodika

69

Číslo periodika v rámci svazku

6-7

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

47

Strana od-do

1383-1429

Kód UT WoS článku

000344917300003

EID výsledku v databázi Scopus

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