Influencing the Effect of Treatment of Diseases Related to Bone Remodelling by Dynamic Loading

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F10%3A00170498" target="_blank" >RIV/68407700:21340/10:00170498 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Influencing the Effect of Treatment of Diseases Related to Bone Remodelling by Dynamic Loading

Popis výsledku v původním jazyce

In this chapter, a more detailed influences of various biochemical factors will be added into the bone remodelling model through the RANKL-RANK-OPG chain mediating the effects of majority of acting hormones, growth factors, and cytokines. Physical activity (dynamic loading) is very essential in bone adaptation process. Actually, because it has a significant promoting effect on bone formation, it can be used for "treatment" of low bone mass. The addition of control factors will enable to predict concreteeffects of changes of serum levels of these control factors of bone remodelling such as estrogen or NO. Several diseases and their possible treatment is simulated, e.g. influence of menopause, hyperparathyroidism, and disuse. The importance of proper exercise will be apparent and its significant contribution to bone tissue formation as well. However, still in more severe cases only the simultaneous treatment with medicaments and increase in exercise can reach the desired ef

Název v anglickém jazyce

Influencing the Effect of Treatment of Diseases Related to Bone Remodelling by Dynamic Loading

Popis výsledku anglicky

In this chapter, a more detailed influences of various biochemical factors will be added into the bone remodelling model through the RANKL-RANK-OPG chain mediating the effects of majority of acting hormones, growth factors, and cytokines. Physical activity (dynamic loading) is very essential in bone adaptation process. Actually, because it has a significant promoting effect on bone formation, it can be used for "treatment" of low bone mass. The addition of control factors will enable to predict concreteeffects of changes of serum levels of these control factors of bone remodelling such as estrogen or NO. Several diseases and their possible treatment is simulated, e.g. influence of menopause, hyperparathyroidism, and disuse. The importance of proper exercise will be apparent and its significant contribution to bone tissue formation as well. However, still in more severe cases only the simultaneous treatment with medicaments and increase in exercise can reach the desired ef

Druh

C - Kapitola v odborné knize

CEP obor

BO - Biofyzika

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Dynamic Modelling

ISBN

978-953-7619-68-8

Počet stran výsledku

28

Strana od-do

—

Počet stran knihy

290

Název nakladatele

In-Teh

Místo vydání

Viena

Kód UT WoS kapitoly

—