Feasible Simulation of Diseases Related to Bone Remodelling and of Their Treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F11%3A00185417" target="_blank" >RIV/68407700:21340/11:00185417 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388998:_____/11:00370475

Výsledek na webu

<a href="http://www.intechopen.com/articles/show/title/feasible-simulation-of-diseases-related-to-bone-remodelling-and-of-their-treatment" target="_blank" >http://www.intechopen.com/articles/show/title/feasible-simulation-of-diseases-related-to-bone-remodelling-and-of-their-treatment</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Feasible Simulation of Diseases Related to Bone Remodelling and of Their Treatment

Popis výsledku v původním jazyce

In this chapter, a more detailed influences of various biochemical factors will be added into the bone remodelling model through the RANKL-RANK-OPG chain mediating the effects of majority of acting hormones, growth factors, and cytokines. Physical activity (dynamic loading) is very essential in bone adaptation process. The addition of control factors will enable to predict concrete effects of changes of serum levels of these control factors of bone remodelling such as PTH, NO. The possibility of including vitamin D and TGF-beta into the model is also being discussed. Several diseases and their possible treatment is simulated, e.g. influence of menopause, hyperparathyroidism, and disuse.

Název v anglickém jazyce

Feasible Simulation of Diseases Related to Bone Remodelling and of Their Treatment

Popis výsledku anglicky

In this chapter, a more detailed influences of various biochemical factors will be added into the bone remodelling model through the RANKL-RANK-OPG chain mediating the effects of majority of acting hormones, growth factors, and cytokines. Physical activity (dynamic loading) is very essential in bone adaptation process. The addition of control factors will enable to predict concrete effects of changes of serum levels of these control factors of bone remodelling such as PTH, NO. The possibility of including vitamin D and TGF-beta into the model is also being discussed. Several diseases and their possible treatment is simulated, e.g. influence of menopause, hyperparathyroidism, and disuse.

Druh

C - Kapitola v odborné knize

CEP obor

FI - Traumatologie a ortopedie

OECD FORD obor

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Projekt

<a href="/cs/project/GA106%2F08%2F0557" target="_blank" >GA106/08/0557: Materiálové vlastnosti žil a jejich remodelace</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Theoretical Biomechanics

ISBN

978-953-307-851-9

Počet stran výsledku

24

Strana od-do

187-210

Počet stran knihy

402

Název nakladatele

InTech

Místo vydání

Rijeka

Kód UT WoS kapitoly

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