The Influence of Receptor-Mediated Interactions on Reaction-Diffusion Mechanisms of Cellular Self-organisation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F12%3A00185080" target="_blank" >RIV/68407700:21340/12:00185080 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388998:_____/12:00376320

Výsledek na webu

<a href="http://www.springerlink.com/content/9713544x6871w4n6/" target="_blank" >http://www.springerlink.com/content/9713544x6871w4n6/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11538-011-9699-4" target="_blank" >10.1007/s11538-011-9699-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Influence of Receptor-Mediated Interactions on Reaction-Diffusion Mechanisms of Cellular Self-organisation

Popis výsledku v původním jazyce

Since its conception in 1952 the Turing model has been a paradigm for pattern formation, motivating numerous theoretical and experimental studies, though its verification at the molecular level in biological systems has remained elusive. In this work, weconsider the influence of receptor-mediated dynamics within the framework of Turing models, showing how non-diffusing species impact the conditions for the emergence of self-organisation. We illustrate our results within the framework of hair follicle pre-patterning, showing how receptor interaction structures can be constrained by the requirement for patterning, without the need for detailed knowledge of the network dynamics. Finally, in the light of our results, we discuss the ability of such systemsto pattern outside the classical limits of the Turing model, and the inherent dangers involved in model reduction.

Název v anglickém jazyce

The Influence of Receptor-Mediated Interactions on Reaction-Diffusion Mechanisms of Cellular Self-organisation

Popis výsledku anglicky

Since its conception in 1952 the Turing model has been a paradigm for pattern formation, motivating numerous theoretical and experimental studies, though its verification at the molecular level in biological systems has remained elusive. In this work, weconsider the influence of receptor-mediated dynamics within the framework of Turing models, showing how non-diffusing species impact the conditions for the emergence of self-organisation. We illustrate our results within the framework of hair follicle pre-patterning, showing how receptor interaction structures can be constrained by the requirement for patterning, without the need for detailed knowledge of the network dynamics. Finally, in the light of our results, we discuss the ability of such systemsto pattern outside the classical limits of the Turing model, and the inherent dangers involved in model reduction.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BA - Obecná matematika

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BULLETIN OF MATHEMATICAL BIOLOGY

ISSN

0092-8240

e-ISSN

—

Svazek periodika

74

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

23

Strana od-do

935-957

Kód UT WoS článku

000301440700007

EID výsledku v databázi Scopus

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