Effect of mobile phase salinity on the Ac-227/Ra-223 generator

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F14%3A00218489" target="_blank" >RIV/68407700:21340/14:00218489 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect of mobile phase salinity on the Ac-227/Ra-223 generator

Popis výsledku v původním jazyce

Radium-223 is the first approved alpha emitting radionuclide for use in radionuclide therapy [1]. Radium follows the Calcium metabolism and thus is self targeted to bones. Several generator systems were described in the past [2]. In this study we have focused on a generator system described by Guseva et al. [3], based on a Dowex-1 resin and a mixed methanol/ nitric acid mobile phase. The effect of NaCl addition into a mobile phase on Ac-227/Th-227/Ra-223 generator was studied. The aim of this study wasto increase the efficiency of Ra-223 elution and improvement of the Ra-223 elution peak shape. Possible Th-227 breakthrough was also evaluated. Acknowledgement: This work was supported by the Ministry of Education Youth and Sports of the Czech republic,grant No.: LK21310.

Název v anglickém jazyce

Effect of mobile phase salinity on the Ac-227/Ra-223 generator

Popis výsledku anglicky

Radium-223 is the first approved alpha emitting radionuclide for use in radionuclide therapy [1]. Radium follows the Calcium metabolism and thus is self targeted to bones. Several generator systems were described in the past [2]. In this study we have focused on a generator system described by Guseva et al. [3], based on a Dowex-1 resin and a mixed methanol/ nitric acid mobile phase. The effect of NaCl addition into a mobile phase on Ac-227/Th-227/Ra-223 generator was studied. The aim of this study wasto increase the efficiency of Ra-223 elution and improvement of the Ra-223 elution peak shape. Possible Th-227 breakthrough was also evaluated. Acknowledgement: This work was supported by the Ministry of Education Youth and Sports of the Czech republic,grant No.: LK21310.

Druh

O - Ostatní výsledky

CEP obor

CH - Jaderná a kvantová chemie, fotochemie

OECD FORD obor

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Projekt

<a href="/cs/project/LK21310" target="_blank" >LK21310: Studium transmutace a separace produktů ozařování Ra-226</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů