Preparation and Labelling Hydroxyapatite with 223Ra and 99mTc

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F15%3A00229691" target="_blank" >RIV/68407700:21340/15:00229691 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

slovinština

Název v původním jazyce

Príprava a značenie hydroxyapatitov s 223Ra a 99mTc

Popis výsledku v původním jazyce

The aim of this study was the preparation, studies and investigation of novel nanoparticles suitable for targeted delivery of 223Ra and 99mTc. Preliminary experiments were focused on the synthesis of hydroxyapatite nanoparticles (HANPs) and their affinity to 223Ra and 99mTc. Technetium-99m (99mTc, T1/2 = 6.0 h) is the most commonly used medical radionuclide for diagnostic procedures. Radium?223 is the first ?-emitting radionuclide approved for targeted radionuclide therapy. The physical half-life of 223Ra of 11.4 days is providing sufficient time for the synthesis, distribution and administration of the radiopharmaceutical to patients. HANPs labelling yields with 223Ra were 95 - 100 % and with 99mTc were 93 ? 94 % depending on the reaction conditions.HANPs were studied on FT-IR (Fourier transform infrared spectroscopy), XRPD (X-Ray Powder Diffraction), DLS (Dynamic Light Scattering), and the sizes of nanoparticles were studied at temperatures 80, 120 and 200 °C.

Název v anglickém jazyce

Preparation and Labelling Hydroxyapatite with 223Ra and 99mTc

Popis výsledku anglicky

The aim of this study was the preparation, studies and investigation of novel nanoparticles suitable for targeted delivery of 223Ra and 99mTc. Preliminary experiments were focused on the synthesis of hydroxyapatite nanoparticles (HANPs) and their affinity to 223Ra and 99mTc. Technetium-99m (99mTc, T1/2 = 6.0 h) is the most commonly used medical radionuclide for diagnostic procedures. Radium?223 is the first ?-emitting radionuclide approved for targeted radionuclide therapy. The physical half-life of 223Ra of 11.4 days is providing sufficient time for the synthesis, distribution and administration of the radiopharmaceutical to patients. HANPs labelling yields with 223Ra were 95 - 100 % and with 99mTc were 93 ? 94 % depending on the reaction conditions.HANPs were studied on FT-IR (Fourier transform infrared spectroscopy), XRPD (X-Ray Powder Diffraction), DLS (Dynamic Light Scattering), and the sizes of nanoparticles were studied at temperatures 80, 120 and 200 °C.

Druh

D - Stať ve sborníku

CEP obor

CH - Jaderná a kvantová chemie, fotochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Zborník recenzovaných príspevkov - Študentská vedecká konferencia PriF UK 2015

ISBN

978-80-223-3859-2

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

1035-1040

Název nakladatele

Univerzita Komenského

Místo vydání

Bratislava

Místo konání akce

Bratislava, SR

Datum konání akce

22. 4. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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