THERANOSTIC SUPERPARAMAGNETIC IRON OXIDE NANOVECTORS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F18%3A00323786" target="_blank" >RIV/68407700:21340/18:00323786 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

THERANOSTIC SUPERPARAMAGNETIC IRON OXIDE NANOVECTORS

Popis výsledku v původním jazyce

Superparamagnetic iron oxide nanoparticles (SPIONs) are being widely studied as contrast agents and radionuclide carriers in nuclear medicine and radiology, advantaging of simple preparation, low toxicity, biocompatibility and superparamagnetic properties. Further, SPIONs can be vectorised by an external magnetic field to a target tissue. The scope of our work was the synthesis and characterization of SPIONs and their labelling with: PET radionuclide 18F, 99mTc useful for SPECT diagnostics and with 223Ra for alpha-particle therapy. The magnetite nanoparticles were labelled with 18F (109,7 min), 99mTc (T1/2 = 6 h) and 223Ra (T1/2 = 11,43 d) with excellent yields and their stability was studied for a period of five half-lives in physiological saline, plasma, serum and albumin solution.

Název v anglickém jazyce

THERANOSTIC SUPERPARAMAGNETIC IRON OXIDE NANOVECTORS

Popis výsledku anglicky

Superparamagnetic iron oxide nanoparticles (SPIONs) are being widely studied as contrast agents and radionuclide carriers in nuclear medicine and radiology, advantaging of simple preparation, low toxicity, biocompatibility and superparamagnetic properties. Further, SPIONs can be vectorised by an external magnetic field to a target tissue. The scope of our work was the synthesis and characterization of SPIONs and their labelling with: PET radionuclide 18F, 99mTc useful for SPECT diagnostics and with 223Ra for alpha-particle therapy. The magnetite nanoparticles were labelled with 18F (109,7 min), 99mTc (T1/2 = 6 h) and 223Ra (T1/2 = 11,43 d) with excellent yields and their stability was studied for a period of five half-lives in physiological saline, plasma, serum and albumin solution.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů