Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats (Part 1)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F17%3A00309714" target="_blank" >RIV/68407700:21340/17:00309714 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.tandfonline.com/doi/abs/10.1080/17435390.2017.1306892" target="_blank" >http://www.tandfonline.com/doi/abs/10.1080/17435390.2017.1306892</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/17435390.2017.1306892" target="_blank" >10.1080/17435390.2017.1306892</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats (Part 1)

Popis výsledku v původním jazyce

ubmicrometer TiO2 particles, including nanoparticulate fractions, are used in an increasing variety of consumer products, as food additives and drug delivery applications are envisaged. Beyond exposure of occupational groups this entails an exposure risk to the public. However, nanoparticle translocation from the organ of intake and potential accumulation in secondary organs is poorly understood and in many investigations excessive doses are applied. The present study investigates the biokinetics and clearance of a low single dose (typically 40-400 µg/kg BW) of 48V-radiolabeled, pure TiO2 anatase nanoparticles ([48V]TiO2NP) with a median aggregate/agglomerate size of 70 nm in aqueous suspension after intravenous injection into female Wistar rats. Biokinetics and clearance were followed from 1-hour to 4-weeks. The use of radiolabeled nanoparticles allowed a quantitative [48V]TiO2NP balancing of all organs, tissues, carcass and excretions of each rat without having to account for chemical background levels possibly caused by dietary or environmental titanium exposure. Highest [48V]TiO2NP accumulations were found in liver (95.5%ID on day-1), followed by spleen (2.5%), carcass (1%), skeleton (0.7%) and blood (0.4%). Detectable nanoparticle levels were found in all other organs. The [48V]TiO2NP content in blood decreased rapidly after 24h while the distribution in other organs and tissues remained rather constant until day-28. The present biokinetics study is part 1 of a series of studies comparing biokinetics after three classical routes of intake (intravenous (IV) injection (part 1), ingestion (part 2), intratracheal instillation (part 3)) under identical laboratory conditions, in order to verify the common hypothesis that IV-injection is a suitable predictor for the biokinetics fate of nanoparticles administered by different routes. This hypothesis is disproved by this series of studies.

Název v anglickém jazyce

Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats (Part 1)

Popis výsledku anglicky

ubmicrometer TiO2 particles, including nanoparticulate fractions, are used in an increasing variety of consumer products, as food additives and drug delivery applications are envisaged. Beyond exposure of occupational groups this entails an exposure risk to the public. However, nanoparticle translocation from the organ of intake and potential accumulation in secondary organs is poorly understood and in many investigations excessive doses are applied. The present study investigates the biokinetics and clearance of a low single dose (typically 40-400 µg/kg BW) of 48V-radiolabeled, pure TiO2 anatase nanoparticles ([48V]TiO2NP) with a median aggregate/agglomerate size of 70 nm in aqueous suspension after intravenous injection into female Wistar rats. Biokinetics and clearance were followed from 1-hour to 4-weeks. The use of radiolabeled nanoparticles allowed a quantitative [48V]TiO2NP balancing of all organs, tissues, carcass and excretions of each rat without having to account for chemical background levels possibly caused by dietary or environmental titanium exposure. Highest [48V]TiO2NP accumulations were found in liver (95.5%ID on day-1), followed by spleen (2.5%), carcass (1%), skeleton (0.7%) and blood (0.4%). Detectable nanoparticle levels were found in all other organs. The [48V]TiO2NP content in blood decreased rapidly after 24h while the distribution in other organs and tissues remained rather constant until day-28. The present biokinetics study is part 1 of a series of studies comparing biokinetics after three classical routes of intake (intravenous (IV) injection (part 1), ingestion (part 2), intratracheal instillation (part 3)) under identical laboratory conditions, in order to verify the common hypothesis that IV-injection is a suitable predictor for the biokinetics fate of nanoparticles administered by different routes. This hypothesis is disproved by this series of studies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanotoxicology

ISSN

1743-5390

e-ISSN

1743-5404

Svazek periodika

11

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

434-442

Kód UT WoS článku

000402677100002

EID výsledku v databázi Scopus

—