Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats (Part 2)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F17%3A00309717" target="_blank" >RIV/68407700:21340/17:00309717 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.tandfonline.com/doi/abs/10.1080/17435390.2017.1306893" target="_blank" >http://www.tandfonline.com/doi/abs/10.1080/17435390.2017.1306893</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/17435390.2017.1306893" target="_blank" >10.1080/17435390.2017.1306893</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats (Part 2)

Popis výsledku v původním jazyce

The biokinetics of a size-selected fraction (70nm median size) of commercially available and 48V-radiolabeled [48V]TiO2 nanoparticles has been investigated in female Wistar-Kyoto rats at retention timepoints 1h, 4h, 24h and 7days after oral application of a single dose of an aqueous [48V]TiO2-nanoparticle suspension by intra-esophageal instillation. A completely balanced quantitative body clearance and biokinetics in all organs and tissues was obtained by applying typical [48V]TiO2-nanoparticle doses in the range of 30–80 μg-kg-1 bodyweight, making use of the high sensitivity of the radiotracer technique. The [48V]TiO2-nanoparticle content was corrected for nanoparticles in the residual blood retained in organs and tissue after exsanguination and for 48V-ions not bound to TiO2-nanoparticles. Beyond predominant fecal excretion about 0.6% of the administered dose passed the gastro-intestinal-barrier after -h and about 0.05% were still distributed in the body at day-7, with quantifiable [48V]TiO2-nanoparticle organ concentrations present in liver (0.09ng-g-1), lungs (0.10ng-g-1), kidneys (0.29ng-g-1), brain (0.36ng-g-1), spleen (0.45ng-g-1), uterus (0.55ng-g-1) and skeleton (0.98ng-g-1).

Název v anglickém jazyce

Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats (Part 2)

Popis výsledku anglicky

The biokinetics of a size-selected fraction (70nm median size) of commercially available and 48V-radiolabeled [48V]TiO2 nanoparticles has been investigated in female Wistar-Kyoto rats at retention timepoints 1h, 4h, 24h and 7days after oral application of a single dose of an aqueous [48V]TiO2-nanoparticle suspension by intra-esophageal instillation. A completely balanced quantitative body clearance and biokinetics in all organs and tissues was obtained by applying typical [48V]TiO2-nanoparticle doses in the range of 30–80 μg-kg-1 bodyweight, making use of the high sensitivity of the radiotracer technique. The [48V]TiO2-nanoparticle content was corrected for nanoparticles in the residual blood retained in organs and tissue after exsanguination and for 48V-ions not bound to TiO2-nanoparticles. Beyond predominant fecal excretion about 0.6% of the administered dose passed the gastro-intestinal-barrier after -h and about 0.05% were still distributed in the body at day-7, with quantifiable [48V]TiO2-nanoparticle organ concentrations present in liver (0.09ng-g-1), lungs (0.10ng-g-1), kidneys (0.29ng-g-1), brain (0.36ng-g-1), spleen (0.45ng-g-1), uterus (0.55ng-g-1) and skeleton (0.98ng-g-1).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30108 - Toxicology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanotoxicology

ISSN

1743-5390

e-ISSN

1743-5404

Svazek periodika

11

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

443-453

Kód UT WoS článku

000402677100003

EID výsledku v databázi Scopus

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