Continuous Distending Pressure Effects on Variables Contributing to Oxygenation in Healthy and ARDS Model Pigs during HFOV

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Continuous Distending Pressure Effects on Variables Contributing to Oxygenation in Healthy and ARDS Model Pigs during HFOV

Popis výsledku v původním jazyce

The aim of this study is to evaluate effects of continuous distending pressure (CDP) on variables that contribute to the oxygenation in healthy and ARDS lung model pigs. Methods. In order to simulate a lung disease, lung injury was induced by lavage withnormal saline with detergent in three pigs. HFOV ventilation was applied before and after the lung lavage. CDP was stepwise increased by 2 cmH(2)O, until the maximum CDP (before the lung lavage 32 cmH(2)O and after the lung lavage 42 cmH(2)O) and then it was stepwise decreased by 2 cmH(2)O to the initial value. In this paper we analyzed the following parameters acquired during our experiments: partial pressure of oxygen in arterial blood (PaO2), cardiac output (CO) and mixed venous blood oxygen saturation (SvO(2)). In order to find how both Pat), and CO affected SvO(2) during the increase of CDP before and after lavage, a nonlinear regression fitting of the response in SvO(2) on the predictors (PaO2 and CO) was implemented. Results. Be

Název v anglickém jazyce

Continuous Distending Pressure Effects on Variables Contributing to Oxygenation in Healthy and ARDS Model Pigs during HFOV

Popis výsledku anglicky

The aim of this study is to evaluate effects of continuous distending pressure (CDP) on variables that contribute to the oxygenation in healthy and ARDS lung model pigs. Methods. In order to simulate a lung disease, lung injury was induced by lavage withnormal saline with detergent in three pigs. HFOV ventilation was applied before and after the lung lavage. CDP was stepwise increased by 2 cmH(2)O, until the maximum CDP (before the lung lavage 32 cmH(2)O and after the lung lavage 42 cmH(2)O) and then it was stepwise decreased by 2 cmH(2)O to the initial value. In this paper we analyzed the following parameters acquired during our experiments: partial pressure of oxygen in arterial blood (PaO2), cardiac output (CO) and mixed venous blood oxygen saturation (SvO(2)). In order to find how both Pat), and CO affected SvO(2) during the increase of CDP before and after lavage, a nonlinear regression fitting of the response in SvO(2) on the predictors (PaO2 and CO) was implemented. Results. Be

Druh

D - Stať ve sborníku

CEP obor

BJ - Termodynamika

OECD FORD obor

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Projekt

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Návaznosti

O - Projekt operacniho programu

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

International Conference of Computational Methods in Sciences and Engineering 2014 (ICCMSE)

ISBN

978-0-7354-1255-2

ISSN

0094-243X

e-ISSN

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Počet stran výsledku

5

Strana od-do

962-966

Název nakladatele

American Institute of Physics

Místo vydání

Melville, New York

Místo konání akce

Athens

Datum konání akce

4. 4. 2014

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000346015200204