Models of PaO2 response to the continuous distending pressure maneuver during high frequency oscillatory ventilation in healthy and ARDS lung model pigs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F16%3A00242580" target="_blank" >RIV/68407700:21460/16:00242580 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.tandfonline.com/eprint/cn7bnqbtvaE9p5yUwS5t/full" target="_blank" >http://www.tandfonline.com/eprint/cn7bnqbtvaE9p5yUwS5t/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/01902148.2016.1145307" target="_blank" >10.3109/01902148.2016.1145307</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Models of PaO2 response to the continuous distending pressure maneuver during high frequency oscillatory ventilation in healthy and ARDS lung model pigs

Popis výsledku v původním jazyce

Purpose/Aim: High-frequency oscillatory ventilation (HFOV) is a method of ventilation that theoretically achieves the goals of lung protective ventilation in acute respiratory distress syndrome (ARDS) patients. It is characterized by a rapid delivery of small tidal volumes at high frequencies oscillating around a continuous distending pressure (CDP). Optimization of CDP is not an easy task and it is titrated empirically in the clinical practice. The aim of this study is to investigate whether the level of CDP consistently affects the shape of the partial pressure of oxygen (PaO2) response to stepwise changes in CDP during HFOV of healthy and ARDS-induced pigs. Materials and Methods: We performed two stepwisemaneuvers of CDP in 14 pigs: one before and one after the lung lavage, inducing ARDS. For each CDP step performed,we fitted a segment of PaO2 curvewith a one-term power model. Results: PaO2 course follows shapes modeled by root, linear, quadratic, and cubic functions for values of PaO2 110 mmHg and PaO2 200 mmHg, before and after the lung lavage, respectively. PaO2 course follows a shape modeled exclusively by a root function for values of PaO2 > 110 mmHg and PaO2 > 200 mmHg, before and after the lung lavage, respectively. It is not possible to describe a relationship between the shape of the PaO2 course and the values of CDP. Conclusions: The PaO2 curve may give information about the level of recruitment of alveoli, but cannot be used for optimization of CDP level during HFOV in healthy and ARDS lung model pigs.

Název v anglickém jazyce

Models of PaO2 response to the continuous distending pressure maneuver during high frequency oscillatory ventilation in healthy and ARDS lung model pigs

Popis výsledku anglicky

Purpose/Aim: High-frequency oscillatory ventilation (HFOV) is a method of ventilation that theoretically achieves the goals of lung protective ventilation in acute respiratory distress syndrome (ARDS) patients. It is characterized by a rapid delivery of small tidal volumes at high frequencies oscillating around a continuous distending pressure (CDP). Optimization of CDP is not an easy task and it is titrated empirically in the clinical practice. The aim of this study is to investigate whether the level of CDP consistently affects the shape of the partial pressure of oxygen (PaO2) response to stepwise changes in CDP during HFOV of healthy and ARDS-induced pigs. Materials and Methods: We performed two stepwisemaneuvers of CDP in 14 pigs: one before and one after the lung lavage, inducing ARDS. For each CDP step performed,we fitted a segment of PaO2 curvewith a one-term power model. Results: PaO2 course follows shapes modeled by root, linear, quadratic, and cubic functions for values of PaO2 110 mmHg and PaO2 200 mmHg, before and after the lung lavage, respectively. PaO2 course follows a shape modeled exclusively by a root function for values of PaO2 > 110 mmHg and PaO2 > 200 mmHg, before and after the lung lavage, respectively. It is not possible to describe a relationship between the shape of the PaO2 course and the values of CDP. Conclusions: The PaO2 curve may give information about the level of recruitment of alveoli, but cannot be used for optimization of CDP level during HFOV in healthy and ARDS lung model pigs.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FC - Pneumologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental Lung Research

ISSN

0190-2148

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

87-94

Kód UT WoS článku

000373973600004

EID výsledku v databázi Scopus

2-s2.0-84963764000