Stimulation and detection of mesenchymal stem cells osteogenic differentiation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F14%3A00300752" target="_blank" >RIV/68407700:21460/14:00300752 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Stimulation and detection of mesenchymal stem cells osteogenic differentiation

Popis výsledku v původním jazyce

Loss or injuries of tissue or organ are currently a major issue. Tissue engineering is a relatively new multidisciplinary field that aims to replace tissues using biocompatible materials, cells and stimulating factors, or a combination thereof. Mesenchymal stem cells give rise to the field of regenerative medicine as they are able to differentiate into various cell types after appropriate stimulation. Crucial step in the regeneration of bone is selection of an appropriate scaffold material. It should be biocompatible with an adequate speed of degradation to provide mechanical support for the cells and facilitate synthesis of new bone tissue. Moreover, it should have suitable porosity and large interconnected pores to allow cell migration. Enrichment of such scaffold with bioactive substances would lead to differentiation of MSC. The aim of this project is to select an appropriate combination of chemical and mechanical stimuli to promote osteogenic differentiation of mesenchymal stem cells.

Název v anglickém jazyce

Stimulation and detection of mesenchymal stem cells osteogenic differentiation

Popis výsledku anglicky

Loss or injuries of tissue or organ are currently a major issue. Tissue engineering is a relatively new multidisciplinary field that aims to replace tissues using biocompatible materials, cells and stimulating factors, or a combination thereof. Mesenchymal stem cells give rise to the field of regenerative medicine as they are able to differentiate into various cell types after appropriate stimulation. Crucial step in the regeneration of bone is selection of an appropriate scaffold material. It should be biocompatible with an adequate speed of degradation to provide mechanical support for the cells and facilitate synthesis of new bone tissue. Moreover, it should have suitable porosity and large interconnected pores to allow cell migration. Enrichment of such scaffold with bioactive substances would lead to differentiation of MSC. The aim of this project is to select an appropriate combination of chemical and mechanical stimuli to promote osteogenic differentiation of mesenchymal stem cells.

Druh

O - Ostatní výsledky

CEP obor

EI - Biotechnologie a bionika

OECD FORD obor

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Projekt

<a href="/cs/project/EE.2.3.20.0092" target="_blank" >EE.2.3.20.0092: Rozvoj výzkumného týmu BIO-OPT-XUV na FBMI ČVUT</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů