The Effect of Change of Inspired Oxygen Fraction upon Peripheral Oxygen Saturation in Premature Infant: A Mathematical Model Enhancement

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Effect of Change of Inspired Oxygen Fraction upon Peripheral Oxygen Saturation in Premature Infant: A Mathematical Model Enhancement

Popis výsledku v původním jazyce

Premature infants often suffer from hypoxemia and require oxygen therapy to maintain normal blood oxygen level. Normoxemia is maintained by an adjustment of the fraction of oxygen (FiO2) in the inhaled gas mixture that is set manually or automatically based on peripheral oxygen saturation (SpO2) measured by pulse oximetry. Automatic closed-loop systems for control of oxygenation have many advantages; most importantly the longer time for that SpO2 is kept in the target area. A mathematical model of neonatal oxygen transport was proposed that could be a useful tool for design, validation, and comparison of the automatic control algorithms. In this work we enhanced the original model in two ways. First, a diffusion coefficient was introduced into the compartment that represents the alveolar-capillary membrane and the dynamic response of the overall model was improved. Comparing the SpO2 output of the model with clinical data, R-squared as high as 0.83 was reached. Second, the time delay of O2 delivery after a change of FiO2 during the nCPAP ventilation support was experimentally measured, allowing more realistic performance of the model when simulating closed-loop control of oxygenation.

Název v anglickém jazyce

The Effect of Change of Inspired Oxygen Fraction upon Peripheral Oxygen Saturation in Premature Infant: A Mathematical Model Enhancement

Popis výsledku anglicky

Premature infants often suffer from hypoxemia and require oxygen therapy to maintain normal blood oxygen level. Normoxemia is maintained by an adjustment of the fraction of oxygen (FiO2) in the inhaled gas mixture that is set manually or automatically based on peripheral oxygen saturation (SpO2) measured by pulse oximetry. Automatic closed-loop systems for control of oxygenation have many advantages; most importantly the longer time for that SpO2 is kept in the target area. A mathematical model of neonatal oxygen transport was proposed that could be a useful tool for design, validation, and comparison of the automatic control algorithms. In this work we enhanced the original model in two ways. First, a diffusion coefficient was introduced into the compartment that represents the alveolar-capillary membrane and the dynamic response of the overall model was improved. Comparing the SpO2 output of the model with clinical data, R-squared as high as 0.83 was reached. Second, the time delay of O2 delivery after a change of FiO2 during the nCPAP ventilation support was experimentally measured, allowing more realistic performance of the model when simulating closed-loop control of oxygenation.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20601 - Medical engineering

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů