Computer model of oxygenation in neonates: A demonstration of utility

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F19%3A00333882" target="_blank" >RIV/68407700:21460/19:00333882 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1515/cdbme-2019-0019" target="_blank" >https://doi.org/10.1515/cdbme-2019-0019</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/cdbme-2019-0019" target="_blank" >10.1515/cdbme-2019-0019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Computer model of oxygenation in neonates: A demonstration of utility

Popis výsledku v původním jazyce

Maintaining a prescribed peripheral oxygen saturation (SpO2) target during routine care of neonates is challenging and inspired fraction of oxygen (FiO2) titration practices differ among caregivers and centers. Algorithms for automatic feedback control of SpO2 are being developed and tested, that would adapt to the changing neonatal organism and better maintain the required SpO2 target range. While clinical data is necessary to validate differences in the titration strategies, a continuous physiological model of oxygenation in neonates would facilitate baseline testing of different approaches, manual or automated. The objective of our study was to enhance a mathematical model of oxygenation of the neonate and to compare the performance of the model with available clinical data. We have implemented the diffusion resistance into the model as well as a variable oxyhemoglobin dissociation relationship and the bias between arterial and peripheral oxygen saturation. Values of model parameters were scaled to fit preterm infant scenarios. The comparison of the clinical data and computer simulations suggest that the model can reliably simulate episodes of oxygen desaturation and describe the relation between ventilation, FiO2 and SpO2. It appears that the model may be an effective tool to test manual and automatic FiO2 titration strategies.

Název v anglickém jazyce

Computer model of oxygenation in neonates: A demonstration of utility

Popis výsledku anglicky

Maintaining a prescribed peripheral oxygen saturation (SpO2) target during routine care of neonates is challenging and inspired fraction of oxygen (FiO2) titration practices differ among caregivers and centers. Algorithms for automatic feedback control of SpO2 are being developed and tested, that would adapt to the changing neonatal organism and better maintain the required SpO2 target range. While clinical data is necessary to validate differences in the titration strategies, a continuous physiological model of oxygenation in neonates would facilitate baseline testing of different approaches, manual or automated. The objective of our study was to enhance a mathematical model of oxygenation of the neonate and to compare the performance of the model with available clinical data. We have implemented the diffusion resistance into the model as well as a variable oxyhemoglobin dissociation relationship and the bias between arterial and peripheral oxygen saturation. Values of model parameters were scaled to fit preterm infant scenarios. The comparison of the clinical data and computer simulations suggest that the model can reliably simulate episodes of oxygen desaturation and describe the relation between ventilation, FiO2 and SpO2. It appears that the model may be an effective tool to test manual and automatic FiO2 titration strategies.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Directions in Biomedical Engineering

ISSN

2364-5504

e-ISSN

2364-5504

Svazek periodika

5

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

4

Strana od-do

73-76

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85072642292