An analysis of neural activity of the human basal ganglia in dystonia: A review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F19%3A00340927" target="_blank" >RIV/68407700:21460/19:00340927 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.14311/CTJ.2019.2.05" target="_blank" >https://doi.org/10.14311/CTJ.2019.2.05</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14311/CTJ.2019.2.05" target="_blank" >10.14311/CTJ.2019.2.05</a>

Jazyk výsledku

angličtina

Název v původním jazyce

An analysis of neural activity of the human basal ganglia in dystonia: A review

Popis výsledku v původním jazyce

Deep brain stimulation of the globus pallidus internus is an efective symptomatic treatment for pharmacoresistant dystonic syndromes, where pathophysiological mechanisms of action are not yet fully understood. The aim of this review article is to provide an overview of the state-of-the-art approaches for processing of microelectrode recordings in dystonia; in order to define biomarkers to identify patients who will benefit from the clinical deep brain stimulation. For this purpose, the essential elements of microelectrode processing are examined. Next, we investigate a real example of spike sorting processing in this field. Herein, we describe baseline elements of microrecordings processing including data collection, preprocessing phase, features computation, spike detection and sorting and finally, advanced spike train data analysis. This study will help readers acquire the necessary information about these elements and their associated techniques. Thus, this study is supposed to assist during identification and proposal of interesting clinical hypotheses in the field of single unit neuronal recordings in dystonia.

Název v anglickém jazyce

An analysis of neural activity of the human basal ganglia in dystonia: A review

Popis výsledku anglicky

Deep brain stimulation of the globus pallidus internus is an efective symptomatic treatment for pharmacoresistant dystonic syndromes, where pathophysiological mechanisms of action are not yet fully understood. The aim of this review article is to provide an overview of the state-of-the-art approaches for processing of microelectrode recordings in dystonia; in order to define biomarkers to identify patients who will benefit from the clinical deep brain stimulation. For this purpose, the essential elements of microelectrode processing are examined. Next, we investigate a real example of spike sorting processing in this field. Herein, we describe baseline elements of microrecordings processing including data collection, preprocessing phase, features computation, spike detection and sorting and finally, advanced spike train data analysis. This study will help readers acquire the necessary information about these elements and their associated techniques. Thus, this study is supposed to assist during identification and proposal of interesting clinical hypotheses in the field of single unit neuronal recordings in dystonia.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Lékař a technika

ISSN

0301-5491

e-ISSN

—

Svazek periodika

49

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

66-71

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85078675440