Analysis of Neural Activity of the Human Basal Ganglia in Dystonia: a Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F18%3A00326028" target="_blank" >RIV/68407700:21460/18:00326028 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of Neural Activity of the Human Basal Ganglia in Dystonia: a Review

Popis výsledku v původním jazyce

Dystonia is a painful, disabling disease whose cause in many cases remains unknown. Deep brain stimulation (DBS) is emerging as a viable treatment option for selected patients with dystonia. Intraoperative extracellular microelectrode recordings (MER) are considered as the standard electrophysiological method for the precise positioning of the DBS electrode into the target brain structure. The aim of this article is to provide an overview the state-of-the-art approaches for processing of microelectrode recordings in dystonia in order to define biomarkers to identify patients who will have clinical benefit. For this purpose, the comprehensive elements of microelectrode recording and processing are examined. Next, we investigate the primary and recent studies and objectives in this field. Herein, we describe baseline elements of MER processing including data collection, preprocessing phase, features computation, spike detection and sorting and advanced spike train data analysis. This study will help readers acquire the necessary information about these elements and their associated techniques. Thus, this study is supposed to assist during identification and proposal of interesting clinical hypotheses in the field of single unit neuronal recordings in dystonia.

Název v anglickém jazyce

Analysis of Neural Activity of the Human Basal Ganglia in Dystonia: a Review

Popis výsledku anglicky

Dystonia is a painful, disabling disease whose cause in many cases remains unknown. Deep brain stimulation (DBS) is emerging as a viable treatment option for selected patients with dystonia. Intraoperative extracellular microelectrode recordings (MER) are considered as the standard electrophysiological method for the precise positioning of the DBS electrode into the target brain structure. The aim of this article is to provide an overview the state-of-the-art approaches for processing of microelectrode recordings in dystonia in order to define biomarkers to identify patients who will have clinical benefit. For this purpose, the comprehensive elements of microelectrode recording and processing are examined. Next, we investigate the primary and recent studies and objectives in this field. Herein, we describe baseline elements of MER processing including data collection, preprocessing phase, features computation, spike detection and sorting and advanced spike train data analysis. This study will help readers acquire the necessary information about these elements and their associated techniques. Thus, this study is supposed to assist during identification and proposal of interesting clinical hypotheses in the field of single unit neuronal recordings in dystonia.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů