EFFECT OF INSPIRATORY-TO-EXPIRATORY TIME RATIO AND AMPLITUDE OF OSCILLATIONS ON THE DEVELOPMENT AND MAGNITUDE OF DYNAMIC HYPERINFLATION AND HYPOINFLATION OF LUNGS DURING HFOV

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F22%3A00372280" target="_blank" >RIV/68407700:21460/22:00372280 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.14311/CTJ.2022.2.03" target="_blank" >https://doi.org/10.14311/CTJ.2022.2.03</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14311/CTJ.2022.2.03" target="_blank" >10.14311/CTJ.2022.2.03</a>

Jazyk výsledku

angličtina

Název v původním jazyce

EFFECT OF INSPIRATORY-TO-EXPIRATORY TIME RATIO AND AMPLITUDE OF OSCILLATIONS ON THE DEVELOPMENT AND MAGNITUDE OF DYNAMIC HYPERINFLATION AND HYPOINFLATION OF LUNGS DURING HFOV

Popis výsledku v původním jazyce

During high-frequency oscillatory ventilation (HFOV), a situation may occur where the mean alveolar pressure (mPalv) differs significantly from the mean airway pressure (mPaw). Studies documenting the differences between these pressures during HFOV have documented states of both higher and lower mPalv compared to mPaw. The effect of HFOV parameters on the pressure difference is not yet understood. The aim of this study is to investigate how this phenomenon is affected by the ratio of inspiratory to expiratory time and the amplitude of HFOV oscillations (ΔP). The effect of the listed ventilation parameters was investigated in vitro in seven laboratory models and in vivo on nine pigs. The study found that an inspiratory to expiratory time ratio of 1:1 always results in a positive pressure difference between mPalv and mPaw, referred to as dynamic hyperinflation. At an inspiratory to expiratory ratio of 1:2 this pressure difference is negative in the majority of in vitro models of the respiratory system and in all animals. In addition, the study found that the magnitude of the pressure difference is affected by the ΔP. There is a critical value of ΔP at which the trend of the pressure gradient between the alveolar space and the airways is reversed in relation to the oscillation amplitude.

Název v anglickém jazyce

EFFECT OF INSPIRATORY-TO-EXPIRATORY TIME RATIO AND AMPLITUDE OF OSCILLATIONS ON THE DEVELOPMENT AND MAGNITUDE OF DYNAMIC HYPERINFLATION AND HYPOINFLATION OF LUNGS DURING HFOV

Popis výsledku anglicky

During high-frequency oscillatory ventilation (HFOV), a situation may occur where the mean alveolar pressure (mPalv) differs significantly from the mean airway pressure (mPaw). Studies documenting the differences between these pressures during HFOV have documented states of both higher and lower mPalv compared to mPaw. The effect of HFOV parameters on the pressure difference is not yet understood. The aim of this study is to investigate how this phenomenon is affected by the ratio of inspiratory to expiratory time and the amplitude of HFOV oscillations (ΔP). The effect of the listed ventilation parameters was investigated in vitro in seven laboratory models and in vivo on nine pigs. The study found that an inspiratory to expiratory time ratio of 1:1 always results in a positive pressure difference between mPalv and mPaw, referred to as dynamic hyperinflation. At an inspiratory to expiratory ratio of 1:2 this pressure difference is negative in the majority of in vitro models of the respiratory system and in all animals. In addition, the study found that the magnitude of the pressure difference is affected by the ΔP. There is a critical value of ΔP at which the trend of the pressure gradient between the alveolar space and the airways is reversed in relation to the oscillation amplitude.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Lékař a technika – Clinician and Technology

ISSN

0301-5491

e-ISSN

2336-5552

Svazek periodika

52

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

48-54

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85163319282