Dual MRI-SPECT imaging system realized with Timepix pixel detector inserted into MR small animal scanner

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21670%2F20%3A00344099" target="_blank" >RIV/68407700:21670/20:00344099 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1088/1742-6596/1662/1/012036" target="_blank" >https://doi.org/10.1088/1742-6596/1662/1/012036</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/1742-6596/1662/1/012036" target="_blank" >10.1088/1742-6596/1662/1/012036</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dual MRI-SPECT imaging system realized with Timepix pixel detector inserted into MR small animal scanner

Popis výsledku v původním jazyce

Although MRI and SPECT are routine tools in medical imaging individually, the combination of these two modalities in multimodal imaging is still unexplored. By hybridizing high-resolution anatomical with functional imaging, combined MRI-SPECT could be a valuable addition to existing medical imaging methods, reducing overall scanning time and image coregistration errors. In contrast to PET, SPECT offers a cost-efficient range of applicable radioisotopes. This proof-of-principle study shows a modified experimental MRI-SPECT insert system consisting of an MR-compatible SPECT unit with hybrid semiconductor detectors Timepix. The insert system is equipped with CdTe pixelated sensors, tungsten collimators and a radiofrequency coil (RF). To increase the number of projections acquired, the setup is also equipped with an electromagnetic step motor Microcon SX 16-0503 for a sample rotation. Measurements were performed our own invented multimodal (1H/99mTc) inhomogeneous phantom filled with a liquid 99mTc radiotracer, emitting 140.5 keV γ-rays inside the RF coil by the Bruker BioSpec 47/20 (4.7 T) MR animal scanner. For the evaluation of measured data, SPECT-back projection software was developed in Matlab. Our results pave the way for a preclinical MRI-SPECT insert system. This research was performed in the framework of the Medipix Collaboration

Název v anglickém jazyce

Dual MRI-SPECT imaging system realized with Timepix pixel detector inserted into MR small animal scanner

Popis výsledku anglicky

Although MRI and SPECT are routine tools in medical imaging individually, the combination of these two modalities in multimodal imaging is still unexplored. By hybridizing high-resolution anatomical with functional imaging, combined MRI-SPECT could be a valuable addition to existing medical imaging methods, reducing overall scanning time and image coregistration errors. In contrast to PET, SPECT offers a cost-efficient range of applicable radioisotopes. This proof-of-principle study shows a modified experimental MRI-SPECT insert system consisting of an MR-compatible SPECT unit with hybrid semiconductor detectors Timepix. The insert system is equipped with CdTe pixelated sensors, tungsten collimators and a radiofrequency coil (RF). To increase the number of projections acquired, the setup is also equipped with an electromagnetic step motor Microcon SX 16-0503 for a sample rotation. Measurements were performed our own invented multimodal (1H/99mTc) inhomogeneous phantom filled with a liquid 99mTc radiotracer, emitting 140.5 keV γ-rays inside the RF coil by the Bruker BioSpec 47/20 (4.7 T) MR animal scanner. For the evaluation of measured data, SPECT-back projection software was developed in Matlab. Our results pave the way for a preclinical MRI-SPECT insert system. This research was performed in the framework of the Medipix Collaboration

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

—

OECD FORD obor

30500 - Other medical sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Physics

ISSN

0143-0807

e-ISSN

1361-6404

Svazek periodika

1662

Číslo periodika v rámci svazku

012036

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

2-7

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85096364592