Coaxial nanofibrous scaffold prepared using centrifugal spinning as a drug delivery system for skeletal tissue engineering

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F20%3A00346727" target="_blank" >RIV/68407700:21720/20:00346727 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.4028/www.scientific.net/KEM.834.162" target="_blank" >https://doi.org/10.4028/www.scientific.net/KEM.834.162</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4028/www.scientific.net/KEM.834.162" target="_blank" >10.4028/www.scientific.net/KEM.834.162</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Coaxial nanofibrous scaffold prepared using centrifugal spinning as a drug delivery system for skeletal tissue engineering

Popis výsledku v původním jazyce

Skeletal disorders, caused by trauma, disease, or carcinoma, may result in tissue loss and, finally, in endoprosthesis. Tissue engineering offers an alternative - tissue scaffolds. Its constructs may be seeded with autologous cells or, alternatively, attract cells from the surrounding tissues. Such a scaffold must meet several requirements, such as biocompatibility, biodegradability and suitable morphology for cell attachment and proliferation. Nonetheless, scaffold should stimulate cells migrated from the surrounding tissues to infiltrate the scaffold, proliferate and differentiate to the required cell type. In the current study, we developed a fibrous scaffold with 3D structure using emulsion centrifugal spinning. The scaffold from poly-ε-caprolactone contained a cocktail of growth factors, i.e. TGF-β, IGF and bFGF. The released growth factors enhanced cell proliferation and chondrogenic differentiation. The scaffold is a promising material for skeletal tissue engineering.

Název v anglickém jazyce

Coaxial nanofibrous scaffold prepared using centrifugal spinning as a drug delivery system for skeletal tissue engineering

Popis výsledku anglicky

Skeletal disorders, caused by trauma, disease, or carcinoma, may result in tissue loss and, finally, in endoprosthesis. Tissue engineering offers an alternative - tissue scaffolds. Its constructs may be seeded with autologous cells or, alternatively, attract cells from the surrounding tissues. Such a scaffold must meet several requirements, such as biocompatibility, biodegradability and suitable morphology for cell attachment and proliferation. Nonetheless, scaffold should stimulate cells migrated from the surrounding tissues to infiltrate the scaffold, proliferate and differentiate to the required cell type. In the current study, we developed a fibrous scaffold with 3D structure using emulsion centrifugal spinning. The scaffold from poly-ε-caprolactone contained a cocktail of growth factors, i.e. TGF-β, IGF and bFGF. The released growth factors enhanced cell proliferation and chondrogenic differentiation. The scaffold is a promising material for skeletal tissue engineering.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30213 - Transplantation

Projekt

<a href="/cs/project/NV17-32285A" target="_blank" >NV17-32285A: Funkcionalizovaná nanovlákna v prevenci vzniku kýly v jizvě</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Key Engineering Materials Vol. 834

ISBN

9783035715194

ISSN

1013-9826

e-ISSN

—

Počet stran výsledku

7

Strana od-do

162-168

Název nakladatele

Trans Tech Publications Ltd.

Místo vydání

Pfaffikon

Místo konání akce

Salt lake city

Datum konání akce

2. 8. 2019

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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