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Hydrolat of Helichrysum italicum Promotes Tissue Regeneration During Wound Healing

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F23%3A00373785" target="_blank" >RIV/68407700:21720/23:00373785 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://doi.org/10.33549/physiolres.935101" target="_blank" >https://doi.org/10.33549/physiolres.935101</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.33549/physiolres.935101" target="_blank" >10.33549/physiolres.935101</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Hydrolat of Helichrysum italicum Promotes Tissue Regeneration During Wound Healing

  • Popis výsledku v původním jazyce

    Wound healing is a dynamic process involving different cell types with distinct roles according to the stages of healing. Fibroblasts and stem cells actively participate in tissue regeneration. A proper stimulation could contribute to enhance wound healing processes. Helichrysum italicum (H. italicum) is a medical plant well described for its pharmacological, antimicrobial, and anti-inflammatory activities. Aim of the present work was to examine the effect of the hydrolate derivate from H. italicum on stem cells isolated from skin and fibroblasts in vitro in presence or absence of tissue damage. The viability and proliferation of all cell types cultured in different conditions were analyzed by MTT and BrdU assays. Cell proliferation after wound was analyzed with scratch test. Also, the expression of the main genes involved in tissue repair was evaluated by RT-qPCR analysis. Here we describe the capability of hydrolate of H. italicum to promote tissue regeneration after scratch test both in stem cells and in fibroblasts. Moreover, the gene expression analysis revealed that, hydrolate of H. italicum is also able to enhance stemness related. In conclusion our results are encouraging, highlighting novel regenerative properties of hydrolate of H. italicum and paving the way for future application of this wasting product in accelerating wound healing.

  • Název v anglickém jazyce

    Hydrolat of Helichrysum italicum Promotes Tissue Regeneration During Wound Healing

  • Popis výsledku anglicky

    Wound healing is a dynamic process involving different cell types with distinct roles according to the stages of healing. Fibroblasts and stem cells actively participate in tissue regeneration. A proper stimulation could contribute to enhance wound healing processes. Helichrysum italicum (H. italicum) is a medical plant well described for its pharmacological, antimicrobial, and anti-inflammatory activities. Aim of the present work was to examine the effect of the hydrolate derivate from H. italicum on stem cells isolated from skin and fibroblasts in vitro in presence or absence of tissue damage. The viability and proliferation of all cell types cultured in different conditions were analyzed by MTT and BrdU assays. Cell proliferation after wound was analyzed with scratch test. Also, the expression of the main genes involved in tissue repair was evaluated by RT-qPCR analysis. Here we describe the capability of hydrolate of H. italicum to promote tissue regeneration after scratch test both in stem cells and in fibroblasts. Moreover, the gene expression analysis revealed that, hydrolate of H. italicum is also able to enhance stemness related. In conclusion our results are encouraging, highlighting novel regenerative properties of hydrolate of H. italicum and paving the way for future application of this wasting product in accelerating wound healing.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    21001 - Nano-materials (production and properties)

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/VB01000071" target="_blank" >VB01000071: Zvýšení efektivity záchytu pachových molekul kompozitní nanovlákennou vrstvou pro využití v kriminalistické praxi</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2023

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

    1802-9973

  • Svazek periodika

    72

  • Číslo periodika v rámci svazku

    6

  • Stát vydavatele periodika

    CZ - Česká republika

  • Počet stran výsledku

    10

  • Strana od-do

  • Kód UT WoS článku

    001136613100025

  • EID výsledku v databázi Scopus