C60 Fullerene Derivative: Influence of Nanoparticles Size on Toxicity and Radioprotectvity of Water Soluble Fullerene Derivate

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70565813%3A_____%2F11%3A%230000250" target="_blank" >RIV/70565813:_____/11:#0000250 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

C60 Fullerene Derivative: Influence of Nanoparticles Size on Toxicity and Radioprotectvity of Water Soluble Fullerene Derivate

Popis výsledku v původním jazyce

This work is a follow-up to an earlier one in which we presented the radioprotective properties of a watersoluble C60 fullerene derivative (DF) which had been obtained by a reaction of C60 fullerene with peracetic acid and subsequent hydrolysis. Radioprotective properties were proven in vivo (testing organism ? danio rerio, the concentration of DF solution 147 mg/l) as were its non-toxic properties on this sensitive organism. But we observed cytotoxic properties in vitro on guinea pig kidney cells (as atesting culture) and largely on melanoma cells. In this work we pursued the reasons for cell toxicity. We used the NanoSight LM10HSB analysis for determining the nanoparticle size and concentration in used DF solution of 147 mg/l. It was confirmed thatthe system contained larger particles than 100 nm and was polydispersed. After filtration with a 0,1?m filter and under a 20x and 10x objective, the system showed a nice and quite monodispersed distribution of modal particle size 42 + 53

Název v anglickém jazyce

C60 Fullerene Derivative: Influence of Nanoparticles Size on Toxicity and Radioprotectvity of Water Soluble Fullerene Derivate

Popis výsledku anglicky

This work is a follow-up to an earlier one in which we presented the radioprotective properties of a watersoluble C60 fullerene derivative (DF) which had been obtained by a reaction of C60 fullerene with peracetic acid and subsequent hydrolysis. Radioprotective properties were proven in vivo (testing organism ? danio rerio, the concentration of DF solution 147 mg/l) as were its non-toxic properties on this sensitive organism. But we observed cytotoxic properties in vitro on guinea pig kidney cells (as atesting culture) and largely on melanoma cells. In this work we pursued the reasons for cell toxicity. We used the NanoSight LM10HSB analysis for determining the nanoparticle size and concentration in used DF solution of 147 mg/l. It was confirmed thatthe system contained larger particles than 100 nm and was polydispersed. After filtration with a 0,1?m filter and under a 20x and 10x objective, the system showed a nice and quite monodispersed distribution of modal particle size 42 + 53

Druh

D - Stať ve sborníku

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/VG20102014049" target="_blank" >VG20102014049: Výzkum možností aplikace nových materiálů (se zaměřením na nanomateriály) a progresivních technologií k ochraně osob proti působení CBRN látek s důrazem na kritickou infrastrukturu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2011

ISBN

978-80-87294-23-9

ISSN

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e-ISSN

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Počet stran výsledku

10

Strana od-do

1-10

Název nakladatele

TANGER spol. s r.o.

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

1. 1. 2011

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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