C60 Fullerene Derivative: Influence of Nanoparticle Size on Toxicity and Radioprotectivity of Water Soluble Fullerene Derivative

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70565813%3A_____%2F11%3A%230000251" target="_blank" >RIV/70565813:_____/11:#0000251 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

C60 Fullerene Derivative: Influence of Nanoparticle Size on Toxicity and Radioprotectivity of Water Soluble Fullerene Derivative

Popis výsledku v původním jazyce

This work is a follow-up to an earlier one in which we presented the radioprotective properties of a water-soluble C60 fullerene derivative (DF) which had been obtained by a reaction of C60 fullerene with peracetic acid and subsequent hydrolysis. Radioprotective properties were proven in vivo (testing organism-danio rerio, the concentration of DF solution 147 mg/L) as were its non-toxic properties on this sensitive organism. But we observed cytotoxic properties in vitro on guinea pig kidney cells (as atesting culture) and largely on melanoma cells. In this work we pursued the reasons for cell toxicity. We used the NanoSight LM10HSB analysis for determining the nanoparticle size and concentration in used DF solution of 147 mg/L. It was confirmed that the system contained larger particles than 100 nm and was polydispersed. After filtration with a 0.1 ?m filter and under a 20x and 10xobjective, the system showed a nice and quite monodispersed distribution of modal particle size 42 nm+53

Název v anglickém jazyce

C60 Fullerene Derivative: Influence of Nanoparticle Size on Toxicity and Radioprotectivity of Water Soluble Fullerene Derivative

Popis výsledku anglicky

This work is a follow-up to an earlier one in which we presented the radioprotective properties of a water-soluble C60 fullerene derivative (DF) which had been obtained by a reaction of C60 fullerene with peracetic acid and subsequent hydrolysis. Radioprotective properties were proven in vivo (testing organism-danio rerio, the concentration of DF solution 147 mg/L) as were its non-toxic properties on this sensitive organism. But we observed cytotoxic properties in vitro on guinea pig kidney cells (as atesting culture) and largely on melanoma cells. In this work we pursued the reasons for cell toxicity. We used the NanoSight LM10HSB analysis for determining the nanoparticle size and concentration in used DF solution of 147 mg/L. It was confirmed that the system contained larger particles than 100 nm and was polydispersed. After filtration with a 0.1 ?m filter and under a 20x and 10xobjective, the system showed a nice and quite monodispersed distribution of modal particle size 42 nm+53

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/VG20102014049" target="_blank" >VG20102014049: Výzkum možností aplikace nových materiálů (se zaměřením na nanomateriály) a progresivních technologií k ochraně osob proti působení CBRN látek s důrazem na kritickou infrastrukturu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Materials Science and Engineering

ISSN

1934-8959

e-ISSN

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Svazek periodika

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Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

948-956

Kód UT WoS článku

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EID výsledku v databázi Scopus

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