Study of chemical modification of hyaluronic acid

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of chemical modification of hyaluronic acid

Popis výsledku v původním jazyce

The most important mucopolysaccharide, hyaluronic acid (HA), is a linear carbohydrate polymer. Its disaccharide monomeric unit is built up of N-acetyl D-glucosamine and D-glucuronic acid interconnected via b (1#4) and b (1#4) interglycosidic bonds. In aqueous solutions HA forms rigid domains built up from about 10 - 20 monomer units strongly bound by the systém of intra- and inter- molecular hydrogen bonds, thus producing its characteristics of secondary a tertiary configurations. These structures couldbe strongly influenced by insertion on n-alkyl spacers as a branch into this systems. For this reason, five n-alkyl derivatives on the CH2-OH groups of hyaluronic acid, from n-C6- to n-C16- were prepared. The following properties of these products are reviewed: Kinetic parameters of dissolution, study of enzymatic degradation, thermal analysis and measurements of its electric properties.

Název v anglickém jazyce

Study of chemical modification of hyaluronic acid

Popis výsledku anglicky

The most important mucopolysaccharide, hyaluronic acid (HA), is a linear carbohydrate polymer. Its disaccharide monomeric unit is built up of N-acetyl D-glucosamine and D-glucuronic acid interconnected via b (1#4) and b (1#4) interglycosidic bonds. In aqueous solutions HA forms rigid domains built up from about 10 - 20 monomer units strongly bound by the systém of intra- and inter- molecular hydrogen bonds, thus producing its characteristics of secondary a tertiary configurations. These structures couldbe strongly influenced by insertion on n-alkyl spacers as a branch into this systems. For this reason, five n-alkyl derivatives on the CH2-OH groups of hyaluronic acid, from n-C6- to n-C16- were prepared. The following properties of these products are reviewed: Kinetic parameters of dissolution, study of enzymatic degradation, thermal analysis and measurements of its electric properties.

Druh

D - Stať ve sborníku

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Structure and Stability of Biomacromolecules SSB'01

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

2

Strana od-do

89-90

Název nakladatele

Slovak Academy of Sciences, P. J. Šafárik University

Místo vydání

Košice

Místo konání akce

Košice, Slovenská Republika

Datum konání akce

12. 9. 2001

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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