Study of Structure, Properties and Modifications of Hyaluronic acid and other polysacharides

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of Structure, Properties and Modifications of Hyaluronic acid and other polysacharides

Popis výsledku v původním jazyce

Hyaluronic acid forms in aqueous solution rigid domains built up from about 10-20 monomer units strongly bound by the system of intra - and inter - molecular hydrogen bonds, thus producing its characteristic of secondary and tertiary configurations. These structures could be strongly influenced by insertion on n-alkyl spacers as a branch into this system. For this reason, there were prepared of n-hexyl, and n-octyl deriivates of hyaluronic acid by the procedure described by J. Machr, R. A. Johnstone andM. E. Rose. The polyelectrolyte properties were studied with respect to content of alkyl spacers. The alkylation is reflected in FTIR spectra, DTG and DSC curves as well. Introduction of these spacers increase also induction period of diffusion process of dissolution and decrease of velocity of dissolution as well as a result of polarity of polymer chain changes.

Název v anglickém jazyce

Study of Structure, Properties and Modifications of Hyaluronic acid and other polysacharides

Popis výsledku anglicky

Hyaluronic acid forms in aqueous solution rigid domains built up from about 10-20 monomer units strongly bound by the system of intra - and inter - molecular hydrogen bonds, thus producing its characteristic of secondary and tertiary configurations. These structures could be strongly influenced by insertion on n-alkyl spacers as a branch into this system. For this reason, there were prepared of n-hexyl, and n-octyl deriivates of hyaluronic acid by the procedure described by J. Machr, R. A. Johnstone andM. E. Rose. The polyelectrolyte properties were studied with respect to content of alkyl spacers. The alkylation is reflected in FTIR spectra, DTG and DSC curves as well. Introduction of these spacers increase also induction period of diffusion process of dissolution and decrease of velocity of dissolution as well as a result of polarity of polymer chain changes.

Druh

D - Stať ve sborníku

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Polymery 2002 - programová brožura

ISBN

80-85009-45-5

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

"P30"

Název nakladatele

MACRO

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

16. 9. 2002

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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