Factors influencing encapsulation efficiency of biologically active compound into PLA submikroparticles

Kód výsledku v IS VaVaI

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Nalezeny alternativní kódy

RIV/70883521:28610/11:43866050

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Factors influencing encapsulation efficiency of biologically active compound into PLA submikroparticles

Popis výsledku v původním jazyce

The low molecular weight biodegradable poly(lactide acid) (PLA) was tested as suitable material for encapsulation of bioactive agent into microparticles by the method of emulsification and solvent evaporation at reduced pressure. The attention was focused on the examination of encapsulation capacity for incorporation of a model herbicide. The initial amount of herbicide was altered and parameters characterizing microparticles like encapsulation efficiency, size and shape were evaluated by different methods. Low molecular PLA proved to be a suitable matrix for easy encapsulation of bioactive compounds by the oil-in-water emulsion solvent evaporation method, furthermore without significant changes in particles size. The relative lowest loss of herbicidealong with the highest encapsulation efficiency was achieved for the highest initial concentration of herbicide which is close to the critical concentration under which the particles could still be prepared.

Název v anglickém jazyce

Factors influencing encapsulation efficiency of biologically active compound into PLA submikroparticles

Popis výsledku anglicky

The low molecular weight biodegradable poly(lactide acid) (PLA) was tested as suitable material for encapsulation of bioactive agent into microparticles by the method of emulsification and solvent evaporation at reduced pressure. The attention was focused on the examination of encapsulation capacity for incorporation of a model herbicide. The initial amount of herbicide was altered and parameters characterizing microparticles like encapsulation efficiency, size and shape were evaluated by different methods. Low molecular PLA proved to be a suitable matrix for easy encapsulation of bioactive compounds by the oil-in-water emulsion solvent evaporation method, furthermore without significant changes in particles size. The relative lowest loss of herbicidealong with the highest encapsulation efficiency was achieved for the highest initial concentration of herbicide which is close to the critical concentration under which the particles could still be prepared.

Druh

D - Stať ve sborníku

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Recent Researches in Geography, Geology, Energy, Environment and Biomedicine - Proc. of the 4th WSEAS Int. Conf. on EMESEG'11, 2nd Int. Conf. on WORLD-GEO'11, 5th Int. Conf. on EDEB'11

ISBN

978-1-61804-022-0

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

170-175

Název nakladatele

WSEAS Press (GR)

Místo vydání

Rhodes

Místo konání akce

Corfu Island

Datum konání akce

14. 7. 2011

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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