Preparation and Potential Application of 2-(Indol-2-yl)-3,1-benzoxazin-4-ones

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F12%3A43868090" target="_blank" >RIV/70883521:28110/12:43868090 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Preparation and Potential Application of 2-(Indol-2-yl)-3,1-benzoxazin-4-ones

Popis výsledku v původním jazyce

This paper describes work concerning the preparation of novel benzoxazinones substituted with indole moiety by cyclodehydration of appropriate 2-(indol-2-carboxamido)benzoic acids. A novel route to these acids utilising Fischer indole synthesis has beenalso established. The Fischer reaction precursors were readily obtained from 4 hydroxyquinolin 2-ones by two-step oxidation process. All compounds were characterized by available methods of structural analysis. The original purpose of this work was to prepare a series of title compounds for future testing as ultraviolet absorbers and as additives for the stabilization of polymers. Benzoxazinones can also be useful electrophilic reagents for the synthesis of some biologically active substances. In summary, a novel entry to direct construction of 2-(indol-2-yl)-3,1-benzoxazin-4-one skeleton based on Fischer indole reaction and subsequent dehydration was developed and allows the preparation of a wide variety of substituted benzoxazinones.

Název v anglickém jazyce

Preparation and Potential Application of 2-(Indol-2-yl)-3,1-benzoxazin-4-ones

Popis výsledku anglicky

This paper describes work concerning the preparation of novel benzoxazinones substituted with indole moiety by cyclodehydration of appropriate 2-(indol-2-carboxamido)benzoic acids. A novel route to these acids utilising Fischer indole synthesis has beenalso established. The Fischer reaction precursors were readily obtained from 4 hydroxyquinolin 2-ones by two-step oxidation process. All compounds were characterized by available methods of structural analysis. The original purpose of this work was to prepare a series of title compounds for future testing as ultraviolet absorbers and as additives for the stabilization of polymers. Benzoxazinones can also be useful electrophilic reagents for the synthesis of some biologically active substances. In summary, a novel entry to direct construction of 2-(indol-2-yl)-3,1-benzoxazin-4-one skeleton based on Fischer indole reaction and subsequent dehydration was developed and allows the preparation of a wide variety of substituted benzoxazinones.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Plasty a kaučuk

ISSN

0322-7340

e-ISSN

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Svazek periodika

XLIX

Číslo periodika v rámci svazku

49-Speciál

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

42-47

Kód UT WoS článku

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EID výsledku v databázi Scopus

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