Synthesis of Novel Purine Ribonucleosides Bearing Adamantane Moiety

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F13%3A43870138" target="_blank" >RIV/70883521:28110/13:43870138 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of Novel Purine Ribonucleosides Bearing Adamantane Moiety

Popis výsledku v původním jazyce

Purine nucleosides represent one of the most extensive class of nitrogen heterocycles in the nature with a wide spectrum of significant biological effects. They can act as adenosine receptor ligands, inhibitors of nucleoside transport or antifungal, antiviral and antitumor agents. In this work, several novel purine ribonucleosides bearing a unique adamantylated amines in the 6-position were synthesized in multi-step procedure from starting commercially available hypoxanthine and D-(?)-ribose. Adamantylated aromatic amines were prepared following previously published procedure. The introduction of highly lipophilic adamantyl moiety into the purine pharmacophore can lead to the interesting pharmacological profile of final molecules. All prepared compounds were fully characterised using spectral methods.

Název v anglickém jazyce

Synthesis of Novel Purine Ribonucleosides Bearing Adamantane Moiety

Popis výsledku anglicky

Purine nucleosides represent one of the most extensive class of nitrogen heterocycles in the nature with a wide spectrum of significant biological effects. They can act as adenosine receptor ligands, inhibitors of nucleoside transport or antifungal, antiviral and antitumor agents. In this work, several novel purine ribonucleosides bearing a unique adamantylated amines in the 6-position were synthesized in multi-step procedure from starting commercially available hypoxanthine and D-(?)-ribose. Adamantylated aromatic amines were prepared following previously published procedure. The introduction of highly lipophilic adamantyl moiety into the purine pharmacophore can lead to the interesting pharmacological profile of final molecules. All prepared compounds were fully characterised using spectral methods.

Druh

O - Ostatní výsledky

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů