Preparation of new adamantylated purine ribonucleosides

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Preparation of new adamantylated purine ribonucleosides

Popis výsledku v původním jazyce

Purine ribonucleosides represent one of the most extensive class of nitrogen heterocycles in the nature. A wide range of interesting biological effects of these compounds, such as inhibition of nucleoside transport or antifungal, antiviral and antitumoractivities, is described in the literature. In this work, several novel purine ribonucleosides bearing unique adamantylated amines in the 6-position were synthesized employing a multi-step approach based on sequence of a nucleophilic aromatic substitution, a glycosylation and a deprotection of ribofuranose unit, as it is depicted in Figure 1. Adamantylated aromatic amines introduced at C6 of the purine ring were prepared following previously published procedure. All prepared compounds were obtained in good yields and purity. Their structures were confirmed using spectral methods, e.g. IR, MS and NMR, respectively.

Název v anglickém jazyce

Preparation of new adamantylated purine ribonucleosides

Popis výsledku anglicky

Purine ribonucleosides represent one of the most extensive class of nitrogen heterocycles in the nature. A wide range of interesting biological effects of these compounds, such as inhibition of nucleoside transport or antifungal, antiviral and antitumoractivities, is described in the literature. In this work, several novel purine ribonucleosides bearing unique adamantylated amines in the 6-position were synthesized employing a multi-step approach based on sequence of a nucleophilic aromatic substitution, a glycosylation and a deprotection of ribofuranose unit, as it is depicted in Figure 1. Adamantylated aromatic amines introduced at C6 of the purine ring were prepared following previously published procedure. All prepared compounds were obtained in good yields and purity. Their structures were confirmed using spectral methods, e.g. IR, MS and NMR, respectively.

Druh

O - Ostatní výsledky

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů