Determination of Selenium Species by ICP-MS Method in Biological Samples

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Determination of Selenium Species by ICP-MS Method in Biological Samples

Popis výsledku v původním jazyce

The opinion on selenium influence on human organism has varied in the course of the past century. At first, selenium was considered to be badly toxic up to cancerogenic. As time went by, it was discovered to have an essential role in human organism. In human organism selenium is a part of many enzyme systems, e.g. glutathione peroxidase, and as a part of antioxidant defense system it has an expressive preventive effect against cardiovascular and oncogenic diseases. The toxicity of selenium doesn't only depend on its amount but also on its chemical form or species (oxidation state, organic or inorganic form, eventually the occurrence of single isotopes) and that is why the compounds speciation becomes unavoidable. Many laboratories deal with speciation analysis of various elements, one of which is selenium. Various studies are used in various analytical methods (typically in an online ordering) for the determination of different forms of selenium. However, as the most suitable, in terms of achieving very low detection limits, appears combination HPLC/IC-ICP-MS. In this work are shown the possibilities of this application, recently reported methods for the analysis of various forms of selenium compounds in biological materials [1, 2]. Analytical chemists have increasingly realized that determining total contents of the elements cannot provide the required information about mobility, bioavailability, and finally the impact of elements on ecological systems or biological organisms. Only knowledge about the chemical species of the elements can lead to understanding of chemical and biochemical reactions involving these species, thus providing information about toxicity or essentiality. This is why speciation analysis has become an essential tool for risk assessment of elements in the environment, leading to more effective diagnosis and therapy, to understanding the toxicity and the moving of trace elements and to better nutrition and health.

Název v anglickém jazyce

Determination of Selenium Species by ICP-MS Method in Biological Samples

Popis výsledku anglicky

The opinion on selenium influence on human organism has varied in the course of the past century. At first, selenium was considered to be badly toxic up to cancerogenic. As time went by, it was discovered to have an essential role in human organism. In human organism selenium is a part of many enzyme systems, e.g. glutathione peroxidase, and as a part of antioxidant defense system it has an expressive preventive effect against cardiovascular and oncogenic diseases. The toxicity of selenium doesn't only depend on its amount but also on its chemical form or species (oxidation state, organic or inorganic form, eventually the occurrence of single isotopes) and that is why the compounds speciation becomes unavoidable. Many laboratories deal with speciation analysis of various elements, one of which is selenium. Various studies are used in various analytical methods (typically in an online ordering) for the determination of different forms of selenium. However, as the most suitable, in terms of achieving very low detection limits, appears combination HPLC/IC-ICP-MS. In this work are shown the possibilities of this application, recently reported methods for the analysis of various forms of selenium compounds in biological materials [1, 2]. Analytical chemists have increasingly realized that determining total contents of the elements cannot provide the required information about mobility, bioavailability, and finally the impact of elements on ecological systems or biological organisms. Only knowledge about the chemical species of the elements can lead to understanding of chemical and biochemical reactions involving these species, thus providing information about toxicity or essentiality. This is why speciation analysis has become an essential tool for risk assessment of elements in the environment, leading to more effective diagnosis and therapy, to understanding the toxicity and the moving of trace elements and to better nutrition and health.

Druh

O - Ostatní výsledky

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů