Bio-Artificial Polymeric System: PVA/CHI/AMP for Healthcare-Associated Infections Novel Treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F18%3A63521336" target="_blank" >RIV/70883521:28110/18:63521336 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/18:63521336

Výsledek na webu

<a href="http://cps.utb.cz/images/aktuality/Sborn%C3%ADk_PLASTKO_2018.pdf" target="_blank" >http://cps.utb.cz/images/aktuality/Sborn%C3%ADk_PLASTKO_2018.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Bio-Artificial Polymeric System: PVA/CHI/AMP for Healthcare-Associated Infections Novel Treatment

Popis výsledku v původním jazyce

An interesting approach for facing healthcare-associated infections has been developed in the last decades. In this matter, a system based on poly (vinyl alcohol) (PVA), and chitosan (CHI) blended with an antibiotic (sodium ampicillin) (AMP) has been proposed as a new bio-artificial polymeric system (BAPS) with remarkable behavior due to the mechanical, physical, and biological properties. Despite of several studies of the antibacterial activity itself of the CHI, this property should be reinforced with an antibacterial substance. For this case, aqueous solutions of PVA at 1 % wt. were mixed with acid solution of CHI at 1 % wt. followed by adding AMP running from 0.3 % to 1.5 % wt. related to the total amount of the polymer. The obtained films were tested with common infectious strains associated with healthcare-associated infections; among them Staphylococcus aureus was included. The prepared BAPS revealed moderate antibacterial activity against the tested bacteria without adding a high antibiotic concentration. The findings of this study suggest the PVA-CHI systems under the presence of a widely used antibiotic as AMP may render effectiveness against bacterial strains and biofilm formation, being a promising view in the design of novel antimicrobial biomaterials potentially suitable for tissue engineering applications.

Název v anglickém jazyce

Bio-Artificial Polymeric System: PVA/CHI/AMP for Healthcare-Associated Infections Novel Treatment

Popis výsledku anglicky

An interesting approach for facing healthcare-associated infections has been developed in the last decades. In this matter, a system based on poly (vinyl alcohol) (PVA), and chitosan (CHI) blended with an antibiotic (sodium ampicillin) (AMP) has been proposed as a new bio-artificial polymeric system (BAPS) with remarkable behavior due to the mechanical, physical, and biological properties. Despite of several studies of the antibacterial activity itself of the CHI, this property should be reinforced with an antibacterial substance. For this case, aqueous solutions of PVA at 1 % wt. were mixed with acid solution of CHI at 1 % wt. followed by adding AMP running from 0.3 % to 1.5 % wt. related to the total amount of the polymer. The obtained films were tested with common infectious strains associated with healthcare-associated infections; among them Staphylococcus aureus was included. The prepared BAPS revealed moderate antibacterial activity against the tested bacteria without adding a high antibiotic concentration. The findings of this study suggest the PVA-CHI systems under the presence of a widely used antibiotic as AMP may render effectiveness against bacterial strains and biofilm formation, being a promising view in the design of novel antimicrobial biomaterials potentially suitable for tissue engineering applications.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Plastko 2018

ISBN

978-80-7454-727-0

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

8

Strana od-do

155-162

Název nakladatele

Univerzita Tomáše Bati ve Zlíně

Místo vydání

Zlín

Místo konání akce

Zlín

Datum konání akce

18. 4. 2018

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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