An interesting approach for hospital-acquired infections. PVA/CHI/AMP as a valuable drug delivery system

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F18%3A63520167" target="_blank" >RIV/70883521:28610/18:63520167 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

An interesting approach for hospital-acquired infections. PVA/CHI/AMP as a valuable drug delivery system

Popis výsledku v původním jazyce

New combination of polymers, synthetic (polyvinyl alcohol-PVA) with naturals counterparts (chitosan-CHI) have been proposed as a new bio-artificial polymeric systems (BAMS) with remarkable behavior due to the mechanical, physical, and biological properties that the final material could possess. These properties may be brought by the harmonious effect of the individual components. In this context, the mentioned combination could be referred as a potential biomedical system used as a hydrogel, biofilm, artificial skin, wound-dressing, or drug delivery system. Regardless of their inherent properties, the lack of bacteriostatic or bactericidal properties have triggered the studies of antibacterial systems which are related to decrease the high costs of medical treatments and death of patients after some surgical procedures. As a matter of fact, the present research has been focused in the study of the performance of a PVA-CHI system. Despite of several studies of the antibacterial activity of the CHI itself, this property should be reinforced with an antibacterial substance such as sodium ampicillin (AMP). For this particular case, aqueous solutions of PVA at 1 % wt were mixed with acid solution of CHI at 1 % wt followed by additions of sodium ampicillin running from 0.3 % to 1.5 % wt related to the total amount of the polymer. The obtained films will be tested with common infectious strains related to hospital-acquired infections; among them Staphylococcus aureus and Eshcerichia coli are included. It is expected that the resultant samples might show reinforced physical properties and enhanced bactericidal activity due to the interactions occur between the polymers. In addition, the AMP is known for its wide antibiotic spectrum that, uniformly distributed, may influence the mechanical behavior of the system, allowing it to be used as a controlled drug delivery system.

Název v anglickém jazyce

An interesting approach for hospital-acquired infections. PVA/CHI/AMP as a valuable drug delivery system

Popis výsledku anglicky

New combination of polymers, synthetic (polyvinyl alcohol-PVA) with naturals counterparts (chitosan-CHI) have been proposed as a new bio-artificial polymeric systems (BAMS) with remarkable behavior due to the mechanical, physical, and biological properties that the final material could possess. These properties may be brought by the harmonious effect of the individual components. In this context, the mentioned combination could be referred as a potential biomedical system used as a hydrogel, biofilm, artificial skin, wound-dressing, or drug delivery system. Regardless of their inherent properties, the lack of bacteriostatic or bactericidal properties have triggered the studies of antibacterial systems which are related to decrease the high costs of medical treatments and death of patients after some surgical procedures. As a matter of fact, the present research has been focused in the study of the performance of a PVA-CHI system. Despite of several studies of the antibacterial activity of the CHI itself, this property should be reinforced with an antibacterial substance such as sodium ampicillin (AMP). For this particular case, aqueous solutions of PVA at 1 % wt were mixed with acid solution of CHI at 1 % wt followed by additions of sodium ampicillin running from 0.3 % to 1.5 % wt related to the total amount of the polymer. The obtained films will be tested with common infectious strains related to hospital-acquired infections; among them Staphylococcus aureus and Eshcerichia coli are included. It is expected that the resultant samples might show reinforced physical properties and enhanced bactericidal activity due to the interactions occur between the polymers. In addition, the AMP is known for its wide antibiotic spectrum that, uniformly distributed, may influence the mechanical behavior of the system, allowing it to be used as a controlled drug delivery system.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů