Preparation and characterization of injectable self-antibacterial gelatin/carrageenan/bacterial cellulose hydrogel scaffolds for wound healing application

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F21%3A63528378" target="_blank" >RIV/70883521:28110/21:63528378 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/21:63528378

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1773224721000952" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1773224721000952</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jddst.2021.102415" target="_blank" >10.1016/j.jddst.2021.102415</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preparation and characterization of injectable self-antibacterial gelatin/carrageenan/bacterial cellulose hydrogel scaffolds for wound healing application

Popis výsledku v původním jazyce

This study reports the preparation of self-crosslinked Schiff base gels using gelatin and oxidized carrageenan gum interpenetrated with bacterial cellulose (BC) as injectable drug delivery systems. The injectable gels were successfully prepared at body temperature upon blending with BC and loaded with bovine serum albumin (as the model drug) to produce scaffolds. The gel scaffolds were characterized via rheological, FTIR, SEM, XRD, TGA and mechanical compression analysis. Gelation kinetics of gels as well as swelling, in vitro degradation and drug release kinetics of gel scaffolds were examined. Results showed that the incorporation of BC to the gel system considerably improved mechanical integrity with remarkable rheological shear-thinning properties. Maximum in vitro cumulative drug release from gel scaffolds was determined as 84.01 ± 3.66% within the studied time interval of 168 h. Further analysis showed that the prepared gel scaffolds possess self-antibacterial properties with growth inhibition capacity against E. coli, S. aureus, and K. pneumonia. In vitro cell cytotoxicity was also performed by MTT assay and results depicted &gt;80% cell viability, which indicates the gel scaffolds are cytocompatible. In conclusion, this paper presents a facile approach to fabricate all-natural crosslinked injectable self-antibacterial gels systems with prospective potential application in wound dressing and tissue regeneration.

Název v anglickém jazyce

Preparation and characterization of injectable self-antibacterial gelatin/carrageenan/bacterial cellulose hydrogel scaffolds for wound healing application

Popis výsledku anglicky

This study reports the preparation of self-crosslinked Schiff base gels using gelatin and oxidized carrageenan gum interpenetrated with bacterial cellulose (BC) as injectable drug delivery systems. The injectable gels were successfully prepared at body temperature upon blending with BC and loaded with bovine serum albumin (as the model drug) to produce scaffolds. The gel scaffolds were characterized via rheological, FTIR, SEM, XRD, TGA and mechanical compression analysis. Gelation kinetics of gels as well as swelling, in vitro degradation and drug release kinetics of gel scaffolds were examined. Results showed that the incorporation of BC to the gel system considerably improved mechanical integrity with remarkable rheological shear-thinning properties. Maximum in vitro cumulative drug release from gel scaffolds was determined as 84.01 ± 3.66% within the studied time interval of 168 h. Further analysis showed that the prepared gel scaffolds possess self-antibacterial properties with growth inhibition capacity against E. coli, S. aureus, and K. pneumonia. In vitro cell cytotoxicity was also performed by MTT assay and results depicted &gt;80% cell viability, which indicates the gel scaffolds are cytocompatible. In conclusion, this paper presents a facile approach to fabricate all-natural crosslinked injectable self-antibacterial gels systems with prospective potential application in wound dressing and tissue regeneration.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

<a href="/cs/project/TH71020005" target="_blank" >TH71020005: Bioaktivní vstřikovatelné hydrogely pro regeneraci měkkých tkání po rekonstrukčních maxilofaciálních operacích</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Drug Delivery Science and Technology

ISSN

1773-2247

e-ISSN

—

Svazek periodika

63

Číslo periodika v rámci svazku

Neuveden

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

—

Kód UT WoS článku

000670348300006

EID výsledku v databázi Scopus

2-s2.0-85101615231