Preparation of silk / polycaprolactone porous scaffolds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63571178" target="_blank" >RIV/70883521:28110/23:63571178 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/23:63571178

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Preparation of silk / polycaprolactone porous scaffolds

Popis výsledku v původním jazyce

The conformational transition of the secondary structure of silk fibroin due to shear stress complicates its processability using 3D printing techniques. Therefore, mixtures of polycaprolactone (PCL) with fibroin in various solvents were prepared. From these mixtures, 3D objects were created by electrospinning and extrusion 3D printing. In case of PCL solution, the effect of used solvent and processing temperature on the formation of porous structure was observed. The arrangement of macromolecules in the printouts from fibroin with PCL solution was analyzed. Using atomic force microscopy (AFM), we observed formation of polycaprolactone spherulites which were disrupted by the incorporated fibroin in the form of nano to micro particulate structures. The organization of the lamellae of the PCL spherulites and topography of the printed structures was rearranged by phase separation process caused by poor solvent in the printing dope.

Název v anglickém jazyce

Preparation of silk / polycaprolactone porous scaffolds

Popis výsledku anglicky

The conformational transition of the secondary structure of silk fibroin due to shear stress complicates its processability using 3D printing techniques. Therefore, mixtures of polycaprolactone (PCL) with fibroin in various solvents were prepared. From these mixtures, 3D objects were created by electrospinning and extrusion 3D printing. In case of PCL solution, the effect of used solvent and processing temperature on the formation of porous structure was observed. The arrangement of macromolecules in the printouts from fibroin with PCL solution was analyzed. Using atomic force microscopy (AFM), we observed formation of polycaprolactone spherulites which were disrupted by the incorporated fibroin in the form of nano to micro particulate structures. The organization of the lamellae of the PCL spherulites and topography of the printed structures was rearranged by phase separation process caused by poor solvent in the printing dope.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

20501 - Materials engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů