The Composition Optimization of Curcumin-Loaded Double Oil–Water–Oil Emulsions and Their Stability Evaluation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F24%3A63576998" target="_blank" >RIV/70883521:28110/24:63576998 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/1420-3049/29/17/4035" target="_blank" >https://www.mdpi.com/1420-3049/29/17/4035</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules29174035" target="_blank" >10.3390/molecules29174035</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Composition Optimization of Curcumin-Loaded Double Oil–Water–Oil Emulsions and Their Stability Evaluation

Popis výsledku v původním jazyce

This study aimed to optimize the preparation of multiple oil–water–oil (O/W/O) emulsions using varying amounts of Tween 20 emulsifier, different homogenization methods, and optimal prepa-ration temperatures as carriers for encapsulated curcumin. Following the optimization process, the optimal preparation temperature was found to be 25 °C, with a homogenization speed of 10,000 RPM and an emulsifier concentration of 0.5% Tween 20. Subsequently, the effects of physi-cochemical and viscoelastic properties on the different types of oils used in the outer phase, as well as the impact of storage time, were monitored. The novelty of this work lies in its comprehensive analysis of the stability and encapsulation efficiency of multiple emulsions using various oils, an area that has not been extensively explored before. After identifying the optimal preparation procedure, all samples with different edible oils demonstrated excellent stability and encapsulation efficiency, showing minimal variation in results. The most stable multiple emulsion was found to be the one with coconut oil in the outer phase, exhibiting half the particle size compared to other samples and the lowest encapsulation efficiency losses over 50 days of storage. This study pro-vides new insights into the formulation of stable multiple emulsions for the effective delivery of curcumin and similar bioactive compounds.

Název v anglickém jazyce

The Composition Optimization of Curcumin-Loaded Double Oil–Water–Oil Emulsions and Their Stability Evaluation

Popis výsledku anglicky

This study aimed to optimize the preparation of multiple oil–water–oil (O/W/O) emulsions using varying amounts of Tween 20 emulsifier, different homogenization methods, and optimal prepa-ration temperatures as carriers for encapsulated curcumin. Following the optimization process, the optimal preparation temperature was found to be 25 °C, with a homogenization speed of 10,000 RPM and an emulsifier concentration of 0.5% Tween 20. Subsequently, the effects of physi-cochemical and viscoelastic properties on the different types of oils used in the outer phase, as well as the impact of storage time, were monitored. The novelty of this work lies in its comprehensive analysis of the stability and encapsulation efficiency of multiple emulsions using various oils, an area that has not been extensively explored before. After identifying the optimal preparation procedure, all samples with different edible oils demonstrated excellent stability and encapsulation efficiency, showing minimal variation in results. The most stable multiple emulsion was found to be the one with coconut oil in the outer phase, exhibiting half the particle size compared to other samples and the lowest encapsulation efficiency losses over 50 days of storage. This study pro-vides new insights into the formulation of stable multiple emulsions for the effective delivery of curcumin and similar bioactive compounds.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21101 - Food and beverages

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecules

ISSN

1420-3049

e-ISSN

1420-3049

Svazek periodika

29

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

15

Strana od-do

4035

Kód UT WoS článku

001310936600001

EID výsledku v databázi Scopus

2-s2.0-85204111691