3D printing and electrospinning of PVDF terpolymer and polycaprolactone for biomedical applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F24%3A63580258" target="_blank" >RIV/70883521:28110/24:63580258 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/24:63580258

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

3D printing and electrospinning of PVDF terpolymer and polycaprolactone for biomedical applications

Popis výsledku v původním jazyce

This work explores the processability of a commonly used biomaterial polycaprolactone and a synthetic poly(vinylidene fluoride-trifluoroethylene-chlorotrifluoroethylene) (PVDF-TrFE-CTFE). Polycaprolactone (PCL) is a biocompatible, biodegradable and low bioactive polymer with easy processability, making it suitable for tissue engineering and biomedical applications. (PVDF-TrFE-CTFE) is an electroactive polymer that has gained attention in the field of tissue engineering because of its unique combination of piezoelectric and ferroelectric properties.The work aimed to prepare 3D printed objects with a structured surface on the extruded fibers from PCL/PVDF-TrFE-CTFE blends. Surface texturization typically provides higher surface area which can improve cell adhesion or impact cellular morphology, both important for enhanced biocompatibility of scaffolds tissueengineering. To obtain objects with structured surfaces, a phase separation method based on the dissolution of the polymers in a combination of good and poor solvents was used. The solutions were further processed by extrusion 3D printing or electrospinning. Final fibre morphologies were analysed by microscopic methods to evaluate the effects of the solvents and process parameters on the fiber textures. Concerning the possible use of the final structures for biomedical applications, the residual solvents in the samples were analysed by infrared spectroscopy to confirm their absence.

Název v anglickém jazyce

3D printing and electrospinning of PVDF terpolymer and polycaprolactone for biomedical applications

Popis výsledku anglicky

This work explores the processability of a commonly used biomaterial polycaprolactone and a synthetic poly(vinylidene fluoride-trifluoroethylene-chlorotrifluoroethylene) (PVDF-TrFE-CTFE). Polycaprolactone (PCL) is a biocompatible, biodegradable and low bioactive polymer with easy processability, making it suitable for tissue engineering and biomedical applications. (PVDF-TrFE-CTFE) is an electroactive polymer that has gained attention in the field of tissue engineering because of its unique combination of piezoelectric and ferroelectric properties.The work aimed to prepare 3D printed objects with a structured surface on the extruded fibers from PCL/PVDF-TrFE-CTFE blends. Surface texturization typically provides higher surface area which can improve cell adhesion or impact cellular morphology, both important for enhanced biocompatibility of scaffolds tissueengineering. To obtain objects with structured surfaces, a phase separation method based on the dissolution of the polymers in a combination of good and poor solvents was used. The solutions were further processed by extrusion 3D printing or electrospinning. Final fibre morphologies were analysed by microscopic methods to evaluate the effects of the solvents and process parameters on the fiber textures. Concerning the possible use of the final structures for biomedical applications, the residual solvents in the samples were analysed by infrared spectroscopy to confirm their absence.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

20501 - Materials engineering

Projekt

<a href="/cs/project/NU23-08-00243" target="_blank" >NU23-08-00243: Funkční náhrady pro regeneraci nervových tkání připravované pomocí pokročilých 3D tiskových technik</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů