Covalently conjugated polypyrrole-chitosan nanofibrous conductive composites prepared using dialdehyde polysaccharide linkers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F25%3A63594680" target="_blank" >RIV/70883521:28110/25:63594680 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/25:63594680

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0141813025024742?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0141813025024742?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2025.141923" target="_blank" >10.1016/j.ijbiomac.2025.141923</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Covalently conjugated polypyrrole-chitosan nanofibrous conductive composites prepared using dialdehyde polysaccharide linkers

Popis výsledku v původním jazyce

Polypyrrole (PPy) composites, despite their conductivity and bioactivity, are prone to degradation (e.g., exfoliation or delamination) due to the lack of chemical bonds between PPy and the matrix. Rather than suppressing this degradation through laborious methods involving toxic organic linkers or custom pyrrole derivatives to achieve covalently bonded PPy composites, this study introduces a novel polysaccharide-based approach. This method uses dialdehyde polysaccharides (DAPs) to conjugate PPy to chitosan nanofibers (CHITs) covalently. DAPs stabilize CHITs through Schiff base chemistry and then conjugate pyrrole via aldol condensation. During subsequent polymerization, the conjugated pyrrole is incorporated into the PPy layer formed around the CHITs, covalently linking both polymers. The resulting composites exhibit good conductivity and cytocompatibility, making them promising for biomedical applications and tissue engineering. Moreover, this method is not limited to chitosan but can be extended to other amine-containing substrates.

Název v anglickém jazyce

Covalently conjugated polypyrrole-chitosan nanofibrous conductive composites prepared using dialdehyde polysaccharide linkers

Popis výsledku anglicky

Polypyrrole (PPy) composites, despite their conductivity and bioactivity, are prone to degradation (e.g., exfoliation or delamination) due to the lack of chemical bonds between PPy and the matrix. Rather than suppressing this degradation through laborious methods involving toxic organic linkers or custom pyrrole derivatives to achieve covalently bonded PPy composites, this study introduces a novel polysaccharide-based approach. This method uses dialdehyde polysaccharides (DAPs) to conjugate PPy to chitosan nanofibers (CHITs) covalently. DAPs stabilize CHITs through Schiff base chemistry and then conjugate pyrrole via aldol condensation. During subsequent polymerization, the conjugated pyrrole is incorporated into the PPy layer formed around the CHITs, covalently linking both polymers. The resulting composites exhibit good conductivity and cytocompatibility, making them promising for biomedical applications and tissue engineering. Moreover, this method is not limited to chitosan but can be extended to other amine-containing substrates.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA24-11534S" target="_blank" >GA24-11534S: Vodivé (bio)polymerní kompozity s kovalentně vázaným polypyrrolem pro biomedicínské aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

1879-0003

Svazek periodika

307

Číslo periodika v rámci svazku

Part 3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

nestránkováno

Kód UT WoS článku

001450598000001

EID výsledku v databázi Scopus

2-s2.0-86000759339