Dialdehyde Polysaccharides for the Sustainable Synthesis of Multifunctional Conductive Biomaterials

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F25%3A63594499" target="_blank" >RIV/70883521:28610/25:63594499 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dialdehyde Polysaccharides for the Sustainable Synthesis of Multifunctional Conductive Biomaterials

Popis výsledku v původním jazyce

The advancement of bioelectronics and tissue engineering relies on developing sustainable and biocompatible conductive materials. While conductive polymers like polypyrrole (PPy) show promise, their traditional synthesis methods are often using highly toxic and environmentally harmful reagents.Here, we describe a novel, green synthesis of conductive biomaterials, based on dialdehyde polysaccharides (DAPs), serving as both the template and chemical initiator for pyrrole polymerization [1,2]. The core of the method lies in the newly discovered spontaneous aldol condensation reaction between DAPs and pyrrole that occurs in water at ambient conditions [3].In the first step, this versatile method allows for the efficient functionalization of various DAPs (derived e.g. from cellulose, hyaluronate, alginate, or dextran) with pyrrole and its derivatives. The reaction is highly efficient, allowing straightforward immobilization of pyrrole cycles for modification of surface properties or immobilization of pyrrole-based drugs. Moreover, the intrinsic polyaldehydic structure of DAPs can be used to initiate the spontaneous polymerization of pyrrole, resulting in covalently bonded DAP/PPy composites with good conductivity and greatly improved durability. DAP also acts as a template, allowing the preparation of various conductive materials, from nanoparticles and nanofibers to hydrogels, textiles, and 3D hierarchical structures.Comprehensive characterization using FTIR, NMR, SEM, TEM, and electrochemical methods was performed to clarify the reaction mechanism and properties of the prepared materials. Furthermore, biological assays demonstrated excellent cytocompatibility along with significant antioxidative, anti-inflammatory, and immunomodulatory effects and wound healing acceleration.To summarize, this work establishes dialdehyde polysaccharides as a versatile and sustainable platform for the eco-friendly synthesis of advanced conductive biomaterials, opening new avenues for applications in biosensors and advanced wound dressings, with potential uses also in wearable electronics and energy storage.

Název v anglickém jazyce

Dialdehyde Polysaccharides for the Sustainable Synthesis of Multifunctional Conductive Biomaterials

Popis výsledku anglicky

The advancement of bioelectronics and tissue engineering relies on developing sustainable and biocompatible conductive materials. While conductive polymers like polypyrrole (PPy) show promise, their traditional synthesis methods are often using highly toxic and environmentally harmful reagents.Here, we describe a novel, green synthesis of conductive biomaterials, based on dialdehyde polysaccharides (DAPs), serving as both the template and chemical initiator for pyrrole polymerization [1,2]. The core of the method lies in the newly discovered spontaneous aldol condensation reaction between DAPs and pyrrole that occurs in water at ambient conditions [3].In the first step, this versatile method allows for the efficient functionalization of various DAPs (derived e.g. from cellulose, hyaluronate, alginate, or dextran) with pyrrole and its derivatives. The reaction is highly efficient, allowing straightforward immobilization of pyrrole cycles for modification of surface properties or immobilization of pyrrole-based drugs. Moreover, the intrinsic polyaldehydic structure of DAPs can be used to initiate the spontaneous polymerization of pyrrole, resulting in covalently bonded DAP/PPy composites with good conductivity and greatly improved durability. DAP also acts as a template, allowing the preparation of various conductive materials, from nanoparticles and nanofibers to hydrogels, textiles, and 3D hierarchical structures.Comprehensive characterization using FTIR, NMR, SEM, TEM, and electrochemical methods was performed to clarify the reaction mechanism and properties of the prepared materials. Furthermore, biological assays demonstrated excellent cytocompatibility along with significant antioxidative, anti-inflammatory, and immunomodulatory effects and wound healing acceleration.To summarize, this work establishes dialdehyde polysaccharides as a versatile and sustainable platform for the eco-friendly synthesis of advanced conductive biomaterials, opening new avenues for applications in biosensors and advanced wound dressings, with potential uses also in wearable electronics and energy storage.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20901 - Industrial biotechnology

Projekt

<a href="/cs/project/GA24-11534S" target="_blank" >GA24-11534S: Vodivé (bio)polymerní kompozity s kovalentně vázaným polypyrrolem pro biomedicínské aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů