DIALDEHYDE POLYSACCHARIDE-POLYPYRROLE COPOLYMERS: GREEN SYNTHESIS AND PROMISING BIOMEDICAL PROPERTIES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F25%3A63595418" target="_blank" >RIV/70883521:28610/25:63595418 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

DIALDEHYDE POLYSACCHARIDE-POLYPYRROLE COPOLYMERS: GREEN SYNTHESIS AND PROMISING BIOMEDICAL PROPERTIES

Popis výsledku v původním jazyce

The development of sustainable and biocompatible conductive materials is crucial foradvancements in bioelectronics and tissue engineering. Materials based on conductivepolymers such as polypyrrole (PPy) are particularly promising. However, they suffer fromseveral drawbacks, including rather harsh and problematic synthesis.This study presents a novel polysaccharide-based method for synthesizing conductive andhighly biocompatible materials using a newly discovered aldol condensation reaction betweendialdehyde polysaccharides (DAPs) and pyrrole. The reaction is spontaneous and runs inwater under mild conditions, eliminating the need for harsh oxidants or catalysts used inconventional PPy synthesis.This approach is highly versatile, allowing:(a) Efficient functionalization of various DAPs with pyrrole and its derivatives, e.g. tochange their surface properties or immobilize drugs;(b) Spontaneous in situ polymerization of pyrrole, facilitated by the uniquepolyaldehydic character of various DAPs based on cellulose, hyaluronate, or alginate;(c) Fabrication of highly conductive nanofibrous DAP/PPy composites with improveddurability and resilience due to covalent links between polysaccharide matrix and PPy.Spectroscopic techniques (FTIR, NMR), microscopy (SEM, TEM), and electrochemicalanalyses were employed to elucidate the reaction mechanism and properties of thesematerials.The study also investigates the bioactivity of these materials, revealing very low cytotoxicityand significant antioxidative, anti-inflammatory, and immunomodulatory effects, suggestingapplications in biosensors or advanced wound dressings.This work highlights the feasibility of creating high-performance, sustainable materials throughthe utilization of polysaccharide chemistry, offering a promising avenue for the development ofnext-generation conductive biomaterials.

Název v anglickém jazyce

DIALDEHYDE POLYSACCHARIDE-POLYPYRROLE COPOLYMERS: GREEN SYNTHESIS AND PROMISING BIOMEDICAL PROPERTIES

Popis výsledku anglicky

The development of sustainable and biocompatible conductive materials is crucial foradvancements in bioelectronics and tissue engineering. Materials based on conductivepolymers such as polypyrrole (PPy) are particularly promising. However, they suffer fromseveral drawbacks, including rather harsh and problematic synthesis.This study presents a novel polysaccharide-based method for synthesizing conductive andhighly biocompatible materials using a newly discovered aldol condensation reaction betweendialdehyde polysaccharides (DAPs) and pyrrole. The reaction is spontaneous and runs inwater under mild conditions, eliminating the need for harsh oxidants or catalysts used inconventional PPy synthesis.This approach is highly versatile, allowing:(a) Efficient functionalization of various DAPs with pyrrole and its derivatives, e.g. tochange their surface properties or immobilize drugs;(b) Spontaneous in situ polymerization of pyrrole, facilitated by the uniquepolyaldehydic character of various DAPs based on cellulose, hyaluronate, or alginate;(c) Fabrication of highly conductive nanofibrous DAP/PPy composites with improveddurability and resilience due to covalent links between polysaccharide matrix and PPy.Spectroscopic techniques (FTIR, NMR), microscopy (SEM, TEM), and electrochemicalanalyses were employed to elucidate the reaction mechanism and properties of thesematerials.The study also investigates the bioactivity of these materials, revealing very low cytotoxicityand significant antioxidative, anti-inflammatory, and immunomodulatory effects, suggestingapplications in biosensors or advanced wound dressings.This work highlights the feasibility of creating high-performance, sustainable materials throughthe utilization of polysaccharide chemistry, offering a promising avenue for the development ofnext-generation conductive biomaterials.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20901 - Industrial biotechnology

Projekt

<a href="/cs/project/GA24-11534S" target="_blank" >GA24-11534S: Vodivé (bio)polymerní kompozity s kovalentně vázaným polypyrrolem pro biomedicínské aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů