Dietary intakes and exposures to minerals and trace elements from cereal-based mixtures: Potential health benefits and risks for adults

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F25%3A63597379" target="_blank" >RIV/70883521:28110/25:63597379 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2072-6643/17/17/2848" target="_blank" >https://www.mdpi.com/2072-6643/17/17/2848</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nu17172848" target="_blank" >10.3390/nu17172848</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dietary intakes and exposures to minerals and trace elements from cereal-based mixtures: Potential health benefits and risks for adults

Popis výsledku v původním jazyce

Background: Foods containing nutraceuticals from the mineral element group are being developed to compensate for the problem of deficiency in billions of people around the world. This research focuses on essential elements of patented cereal-based mixtures to complement the deficiencies of these elements and, at the same time, assesses their safety in terms of toxic elements in the human diet. Methods: The mineral and trace element contents in the mixtures were determined using the ICP-MS method with a subsequent evaluation of the contributions of the mixtures to the essential and toxic reference values based on dietary intakes and exposures for adults at 60, 80 and 100 kg of adult body weight and a portion size of 50 g. The potential health risk was evaluated using a metal pollution index. Results: The concentrations of minerals and trace elements in the cereal-based mixtures analyzed were as follows: K (up to 4150 µg/g) ≥ P &gt; Mg &gt; Ca &gt; Na &gt; Fe &gt; Zn &gt; Mn &gt; Cu &gt; Al &gt; Ba (up to 4.40 µg/g) &gt; Sr (up to 480 ng/g) ≥ Ti ≥ Ni &gt; Ce ≥ Co &gt; As ≥ Cs &gt; Ag ≥ Li &gt; Se &gt; Be &gt; Cr &gt; Tl &gt; Pb ≥ Hg &gt; Ho &gt; Cd &gt; Sn (up to 1.12 ng/g). The mixtures contribute significantly to the reference values for Mn, Cu, Zn, Fe, and P for adults. Individual dietary exposure values of toxic elements for adults weighing 60 kg decrease in this order: Al (10.1 µg/kg bw/day) &gt; Ni (362 ng/kg bw/day) &gt; As ≥ Pb &gt; Ag &gt; Hg &gt; Cd &gt; and Sn (0.93 ng/kg bw/day). Conclusions: In terms of Regulation (EU) No 1924/2006 of the European Parliament and of the Council on nutrition and health claims made on foods, the cereal-based mixtures could be labelled “source of” Mn, Cu, Zn, Fe, and P when their contributions to the reference values exceeded 15%; in addition, “low sodium/salt” or “very low sodium/salt” can be applied. The mixtures contribute insignificantly to the toxic reference values of Al, Sn, Hg, Cd, Ni, and Ag, and the exposure values of Pb for developmental neurotoxicity, nephrotoxicity, and cardiovascular effects were considered safe. Regarding the metal pollution index of mixtures, there is no concern for potential health effects. Cereal-based mixtures are suitable for use in the food industry as a potential source of beneficial micronutrients for the human diet, although bioaccessible studies should not be neglected.

Název v anglickém jazyce

Dietary intakes and exposures to minerals and trace elements from cereal-based mixtures: Potential health benefits and risks for adults

Popis výsledku anglicky

Background: Foods containing nutraceuticals from the mineral element group are being developed to compensate for the problem of deficiency in billions of people around the world. This research focuses on essential elements of patented cereal-based mixtures to complement the deficiencies of these elements and, at the same time, assesses their safety in terms of toxic elements in the human diet. Methods: The mineral and trace element contents in the mixtures were determined using the ICP-MS method with a subsequent evaluation of the contributions of the mixtures to the essential and toxic reference values based on dietary intakes and exposures for adults at 60, 80 and 100 kg of adult body weight and a portion size of 50 g. The potential health risk was evaluated using a metal pollution index. Results: The concentrations of minerals and trace elements in the cereal-based mixtures analyzed were as follows: K (up to 4150 µg/g) ≥ P &gt; Mg &gt; Ca &gt; Na &gt; Fe &gt; Zn &gt; Mn &gt; Cu &gt; Al &gt; Ba (up to 4.40 µg/g) &gt; Sr (up to 480 ng/g) ≥ Ti ≥ Ni &gt; Ce ≥ Co &gt; As ≥ Cs &gt; Ag ≥ Li &gt; Se &gt; Be &gt; Cr &gt; Tl &gt; Pb ≥ Hg &gt; Ho &gt; Cd &gt; Sn (up to 1.12 ng/g). The mixtures contribute significantly to the reference values for Mn, Cu, Zn, Fe, and P for adults. Individual dietary exposure values of toxic elements for adults weighing 60 kg decrease in this order: Al (10.1 µg/kg bw/day) &gt; Ni (362 ng/kg bw/day) &gt; As ≥ Pb &gt; Ag &gt; Hg &gt; Cd &gt; and Sn (0.93 ng/kg bw/day). Conclusions: In terms of Regulation (EU) No 1924/2006 of the European Parliament and of the Council on nutrition and health claims made on foods, the cereal-based mixtures could be labelled “source of” Mn, Cu, Zn, Fe, and P when their contributions to the reference values exceeded 15%; in addition, “low sodium/salt” or “very low sodium/salt” can be applied. The mixtures contribute insignificantly to the toxic reference values of Al, Sn, Hg, Cd, Ni, and Ag, and the exposure values of Pb for developmental neurotoxicity, nephrotoxicity, and cardiovascular effects were considered safe. Regarding the metal pollution index of mixtures, there is no concern for potential health effects. Cereal-based mixtures are suitable for use in the food industry as a potential source of beneficial micronutrients for the human diet, although bioaccessible studies should not be neglected.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrients

ISSN

2072-6643

e-ISSN

—

Svazek periodika

17

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

24

Strana od-do

nestránkováno

Kód UT WoS článku

001571428000001

EID výsledku v databázi Scopus

2-s2.0-105015894178