Pickering Emulsions Stabilised with Nanostructured Lipid Carriers for Co-Delivery of Lipophilic Bioactive Ingredients

Kód výsledku v IS VaVaI

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RIV/70883521:28610/25:63598798

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Pickering Emulsions Stabilised with Nanostructured Lipid Carriers for Co-Delivery of Lipophilic Bioactive Ingredients

Popis výsledku v původním jazyce

Pickering emulsions (PE) represent a distinct class of emulsions stabilized by solid colloidal particles rather than surfactants, offering enhanced physical stability and high resistance to coalescence due to the practically irreversible adsorption of particles at the oil-water interface.While various nanoparticles have been utilised for PE (cellulose nanocrystals, titanium dioxide), nanostructured lipid carriers (NLCs) have recently emerged as promising PE stabilizers, serving both as stabilizing agents and carriers for lipophilic compounds. A good candidate for encapsulation into NLCs is cannabidiol (CBD) due to its anti-inflammatory and antioxidant properties. Thus, in our study, we developed CBD-NLCs and investigated their potential as stabilizers for PE with additional bioactives (carotenoids and lipophilic vitamins) for co-delivery applications.All CBD-NLCs were prepared via the hot-homogenization method in combination with ultrasound size reduction and quenching. The physicochemical characterization, including particle size distribution, zeta potential, and entrapment efficiency, was performed utilising dynamic light scattering (DLS) and high-efficiency liquid chromatography (HPLC). The resulting CBD-NLCs exhibited high entrapment values (&gt;80%) and a relatively narrow size distribution (~150-200 nm, PdI &lt; 0.4), indicating good stability. Subsequently, CBD-NLCs-PE were prepared by direct ultrasound sonication, yielding emulsions with an average droplet size of 0.6–1.2 µm.Our findings demonstrate that NLCs-PE can provide a promising platform for lipophilic compound encapsulation. This approach has significant potential for pharmaceutical and cosmetic applications, offering a novel strategy for enhanced delivery in topical formulations.

Název v anglickém jazyce

Pickering Emulsions Stabilised with Nanostructured Lipid Carriers for Co-Delivery of Lipophilic Bioactive Ingredients

Popis výsledku anglicky

Pickering emulsions (PE) represent a distinct class of emulsions stabilized by solid colloidal particles rather than surfactants, offering enhanced physical stability and high resistance to coalescence due to the practically irreversible adsorption of particles at the oil-water interface.While various nanoparticles have been utilised for PE (cellulose nanocrystals, titanium dioxide), nanostructured lipid carriers (NLCs) have recently emerged as promising PE stabilizers, serving both as stabilizing agents and carriers for lipophilic compounds. A good candidate for encapsulation into NLCs is cannabidiol (CBD) due to its anti-inflammatory and antioxidant properties. Thus, in our study, we developed CBD-NLCs and investigated their potential as stabilizers for PE with additional bioactives (carotenoids and lipophilic vitamins) for co-delivery applications.All CBD-NLCs were prepared via the hot-homogenization method in combination with ultrasound size reduction and quenching. The physicochemical characterization, including particle size distribution, zeta potential, and entrapment efficiency, was performed utilising dynamic light scattering (DLS) and high-efficiency liquid chromatography (HPLC). The resulting CBD-NLCs exhibited high entrapment values (&gt;80%) and a relatively narrow size distribution (~150-200 nm, PdI &lt; 0.4), indicating good stability. Subsequently, CBD-NLCs-PE were prepared by direct ultrasound sonication, yielding emulsions with an average droplet size of 0.6–1.2 µm.Our findings demonstrate that NLCs-PE can provide a promising platform for lipophilic compound encapsulation. This approach has significant potential for pharmaceutical and cosmetic applications, offering a novel strategy for enhanced delivery in topical formulations.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů