Antibacterial Polyvinyl Chloride/Antibiotic Films: The Effect of Solvent on Morphology, Antibacterial Activity, and Release Kinetics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F10%3A63509211" target="_blank" >RIV/70883521:28610/10:63509211 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antibacterial Polyvinyl Chloride/Antibiotic Films: The Effect of Solvent on Morphology, Antibacterial Activity, and Release Kinetics

Popis výsledku v původním jazyce

Medical-grade polyvinyl chloride was modified with sodium ampicillin in a concentration range from 0 to 5 wt % by solvent casting technique using cyclohexanone and N,N-dimethylformamide. The obtained polymeric systems were characterized by optical microscopy, tensile test, and scanning electron microscopy. In addition, in vitro antibacterial activity against Gram-negative and Gram-positive bacteria were determined by an agar diffusion test. Antibiotic release experiments were performed in distilled water and physiological saline solution, which were monitored by UV-vis spectroscopy. The results showed a crucial role of the solvent on the morphology, antibacterial activity, and releasing characteristic of the ampicillin. Furthermore, a mathematical model was applied to data obtained from release study, to characterize the release kinetics of the ampicillin from the polyvinyl chloride-antibiotic systems.

Název v anglickém jazyce

Antibacterial Polyvinyl Chloride/Antibiotic Films: The Effect of Solvent on Morphology, Antibacterial Activity, and Release Kinetics

Popis výsledku anglicky

Medical-grade polyvinyl chloride was modified with sodium ampicillin in a concentration range from 0 to 5 wt % by solvent casting technique using cyclohexanone and N,N-dimethylformamide. The obtained polymeric systems were characterized by optical microscopy, tensile test, and scanning electron microscopy. In addition, in vitro antibacterial activity against Gram-negative and Gram-positive bacteria were determined by an agar diffusion test. Antibiotic release experiments were performed in distilled water and physiological saline solution, which were monitored by UV-vis spectroscopy. The results showed a crucial role of the solvent on the morphology, antibacterial activity, and releasing characteristic of the ampicillin. Furthermore, a mathematical model was applied to data obtained from release study, to characterize the release kinetics of the ampicillin from the polyvinyl chloride-antibiotic systems.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Polymer Science

ISSN

0021-8995

e-ISSN

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Svazek periodika

118

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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