Thermoplastic modification of medical grade polyvinyl chloride with various antibiotics: Effect of antibiotic chemical structure on mechanical, antibacterial properties, and release activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F11%3A43865600" target="_blank" >RIV/70883521:28110/11:43865600 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/11:43865600

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00289-011-0474-3" target="_blank" >http://dx.doi.org/10.1007/s00289-011-0474-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00289-011-0474-3" target="_blank" >10.1007/s00289-011-0474-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Thermoplastic modification of medical grade polyvinyl chloride with various antibiotics: Effect of antibiotic chemical structure on mechanical, antibacterial properties, and release activity

Popis výsledku v původním jazyce

Novel polymeric systems with antibacterial properties based on medical-grade polyvinyl chloride and antibiotics (Ampicillin, Minocycline, and Rifampicin) in the concentrations up to 1 wt% were prepared by thermoplastic compounding. Thermal stability of the antibiotics was corroborated by IR spectroscopy, X-ray diffraction, differential scanning calorimetry, and 1H nuclear magnetic resonance spectroscopy. The effect of chemical structure on mechanical properties of the prepared systems was determined bytensile testing measurements and correlated with optical microscopy observations. In vitro antibacterial properties of samples were determined by agar diffusion and adhesion test against Gramnegative and Gram-positive bacteria. Antibiotic release experiments in distilled water and physiological saline solution and follow-up detecting by Ultraviolet-Visible spectroscopy were carried out. A mathematical model was applied to evaluate the release kinetics of the antibiotics from prepared pol

Název v anglickém jazyce

Thermoplastic modification of medical grade polyvinyl chloride with various antibiotics: Effect of antibiotic chemical structure on mechanical, antibacterial properties, and release activity

Popis výsledku anglicky

Novel polymeric systems with antibacterial properties based on medical-grade polyvinyl chloride and antibiotics (Ampicillin, Minocycline, and Rifampicin) in the concentrations up to 1 wt% were prepared by thermoplastic compounding. Thermal stability of the antibiotics was corroborated by IR spectroscopy, X-ray diffraction, differential scanning calorimetry, and 1H nuclear magnetic resonance spectroscopy. The effect of chemical structure on mechanical properties of the prepared systems was determined bytensile testing measurements and correlated with optical microscopy observations. In vitro antibacterial properties of samples were determined by agar diffusion and adhesion test against Gramnegative and Gram-positive bacteria. Antibiotic release experiments in distilled water and physiological saline solution and follow-up detecting by Ultraviolet-Visible spectroscopy were carried out. A mathematical model was applied to evaluate the release kinetics of the antibiotics from prepared pol

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polymer Bulletin

ISSN

0170-0839

e-ISSN

—

Svazek periodika

67

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

20

Strana od-do

997-1016

Kód UT WoS článku

000294201900006

EID výsledku v databázi Scopus

—