Partial Hydrolysis of Poly(2-ethyl-2-oxazolines) to Poly(2-oxazoline-co-ethylene imines): Synthesis, Cytotoxicity and Complexing Efficiency with the Perspective for Biomedical Applications

Kód výsledku v IS VaVaI

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RIV/70883521:28110/13:43870732

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Partial Hydrolysis of Poly(2-ethyl-2-oxazolines) to Poly(2-oxazoline-co-ethylene imines): Synthesis, Cytotoxicity and Complexing Efficiency with the Perspective for Biomedical Applications

Popis výsledku v původním jazyce

The versatility of 2-oxazolines and its (co)polymers such as poly (2-ethyl-2-oxazolines) (PETOx) and their ability to form biomaterials has been arising. A living cationic ring opening polymerization of 2-ethyl-2-oxazoline provides poly(2-ethyl-2-oxazolines), which are biocompatible and non-toxic polymers. Poly(ethylene imine), PEI, is well-known polymer used in different biomedical fields such as genetic engineering. However, its cytotoxicity is the main drawback for enhancing its potential in biomedical applications. Therefore, a partial acidic hydrolysis of PETOx leading to compolymer of PETOx with PEI is considered as a suitable way for the preparation of biosafe analogue to PEI. In our work, PETOx with varying molar mass wass prepared and used forthe synthesis of a series of poly(2-ethyl-2oxazoline-co-ethylene imine) copolymers by the controlled hydrolysis of PETOx within the time interval from 15 to 180 min. The structure and composition of the prepared copolymers were determine

Název v anglickém jazyce

Partial Hydrolysis of Poly(2-ethyl-2-oxazolines) to Poly(2-oxazoline-co-ethylene imines): Synthesis, Cytotoxicity and Complexing Efficiency with the Perspective for Biomedical Applications

Popis výsledku anglicky

The versatility of 2-oxazolines and its (co)polymers such as poly (2-ethyl-2-oxazolines) (PETOx) and their ability to form biomaterials has been arising. A living cationic ring opening polymerization of 2-ethyl-2-oxazoline provides poly(2-ethyl-2-oxazolines), which are biocompatible and non-toxic polymers. Poly(ethylene imine), PEI, is well-known polymer used in different biomedical fields such as genetic engineering. However, its cytotoxicity is the main drawback for enhancing its potential in biomedical applications. Therefore, a partial acidic hydrolysis of PETOx leading to compolymer of PETOx with PEI is considered as a suitable way for the preparation of biosafe analogue to PEI. In our work, PETOx with varying molar mass wass prepared and used forthe synthesis of a series of poly(2-ethyl-2oxazoline-co-ethylene imine) copolymers by the controlled hydrolysis of PETOx within the time interval from 15 to 180 min. The structure and composition of the prepared copolymers were determine

Druh

O - Ostatní výsledky

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů