Partialy Hydrolyzed Poly (2-ethyl-2-oxazolines): Synthesis and Cytotoxicity Assay for Biomedical Applications

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Partialy Hydrolyzed Poly (2-ethyl-2-oxazolines): Synthesis and Cytotoxicity Assay for Biomedical Applications

Popis výsledku v původním jazyce

Polymers with the functional groups represent an important aspect in the medical field. 2-oxazolines and its co-polymer represents promising compound in the preparation of biomaterials as potential alternatives to Poly-ethylene glycol (PEG) which has disadvantage of having poor mechanical properties. These classes of synthetic polymers are very versatile and the living cationic polymerization of 2-ethyl-2-oxazolines giving rise to Poly (2-ethyl-2-oxazoline) (PETOx) which are biocompatible, thermo sensitive and non-toxic in nature. On the other hand poly (ethylene imine) (PEI), a highly branched cationic polymer is widely used in the drug delivery as transfecting agents and also in tissue engineering. But the cytotoxic issue is the main drawback in thePEI, so partially hydrolyzed PETOx with its copolymer as PETOx-PEI are prepared so that the cytotoxic level of PEI gets controlled. In this article we report about synthesis and characterization of partially hydrolyzed Poly (2-ethyl-2-oxa

Název v anglickém jazyce

Partialy Hydrolyzed Poly (2-ethyl-2-oxazolines): Synthesis and Cytotoxicity Assay for Biomedical Applications

Popis výsledku anglicky

Polymers with the functional groups represent an important aspect in the medical field. 2-oxazolines and its co-polymer represents promising compound in the preparation of biomaterials as potential alternatives to Poly-ethylene glycol (PEG) which has disadvantage of having poor mechanical properties. These classes of synthetic polymers are very versatile and the living cationic polymerization of 2-ethyl-2-oxazolines giving rise to Poly (2-ethyl-2-oxazoline) (PETOx) which are biocompatible, thermo sensitive and non-toxic in nature. On the other hand poly (ethylene imine) (PEI), a highly branched cationic polymer is widely used in the drug delivery as transfecting agents and also in tissue engineering. But the cytotoxic issue is the main drawback in thePEI, so partially hydrolyzed PETOx with its copolymer as PETOx-PEI are prepared so that the cytotoxic level of PEI gets controlled. In this article we report about synthesis and characterization of partially hydrolyzed Poly (2-ethyl-2-oxa

Druh

D - Stať ve sborníku

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Sborník konference Plastko 2014

ISBN

978-80-7454-335-7

ISSN

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e-ISSN

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Počet stran výsledku

2

Strana od-do

50-52

Název nakladatele

Univerzita Tomáše Bati ve Zlíně

Místo vydání

Zlín

Místo konání akce

Zlín

Datum konání akce

8. 4. 2014

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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