Formulation, antibacterial activity, and cytotoxicity of 1-monoacylglycerol microemulsions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F14%3A43871742" target="_blank" >RIV/70883521:28610/14:43871742 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28110/14:43871742

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ejlt.201300171" target="_blank" >http://dx.doi.org/10.1002/ejlt.201300171</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ejlt.201300171" target="_blank" >10.1002/ejlt.201300171</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Formulation, antibacterial activity, and cytotoxicity of 1-monoacylglycerol microemulsions

Popis výsledku v původním jazyce

Antibacterial activity of stable 1-monoacylglycerol (1-MAG) microemulsions (MEs) of capric (C10:0), undecanoic (C11:0), lauric (C12:0), and myristic (C14:0) acids against the growth of gram-positive and gram-negative bacteria was tested and their inhibition effect was compared to that of neat 1-MAG. To reveal their behavior with respect to eukaryotic cells, the cytotoxicity on mouse fibroblasts was also determined. The MEs were studied via pseudo-ternary phase diagrams in order to find out the miscibility areas of all components used. The results indicated that at 1-MAG concentrations of 1000?1900 mg/L, an inhibition of gram-negative strains was improved compared to neat 1-MAG and depended on the fatty acid type; however, at lower 1-MAG concentrations,both systems showed comparable effect. The opposite trend was detected on gram-positive bacteria, where 1-MAGs showed better performance compared to corresponding MEs. The best antibacterial activity against both bacterial types was obse

Název v anglickém jazyce

Formulation, antibacterial activity, and cytotoxicity of 1-monoacylglycerol microemulsions

Popis výsledku anglicky

Antibacterial activity of stable 1-monoacylglycerol (1-MAG) microemulsions (MEs) of capric (C10:0), undecanoic (C11:0), lauric (C12:0), and myristic (C14:0) acids against the growth of gram-positive and gram-negative bacteria was tested and their inhibition effect was compared to that of neat 1-MAG. To reveal their behavior with respect to eukaryotic cells, the cytotoxicity on mouse fibroblasts was also determined. The MEs were studied via pseudo-ternary phase diagrams in order to find out the miscibility areas of all components used. The results indicated that at 1-MAG concentrations of 1000?1900 mg/L, an inhibition of gram-negative strains was improved compared to neat 1-MAG and depended on the fatty acid type; however, at lower 1-MAG concentrations,both systems showed comparable effect. The opposite trend was detected on gram-positive bacteria, where 1-MAGs showed better performance compared to corresponding MEs. The best antibacterial activity against both bacterial types was obse

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0111" target="_blank" >ED2.1.00/03.0111: Centrum polymerních systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European journal of lipid science and technology

ISSN

1438-7697

e-ISSN

—

Svazek periodika

116

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

448-457

Kód UT WoS článku

000333756000011

EID výsledku v databázi Scopus

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