Non-toxic biodegradable polyester urethanes based on PLA

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43874604" target="_blank" >RIV/70883521:28610/16:43874604 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Non-toxic biodegradable polyester urethanes based on PLA

Popis výsledku v původním jazyce

Polylactide (PLA)-based polymers possess indisputable beneficial properties and they are perfectly convenient for temporary medical applications as drug carriers or resorbable supporting devices. Nevertheless, PLA is also known for its rigidity and low mechanical properties.In this research the polyethylene glycol (PEG) of various molecular weight is used for the synthesis of functionalized PLA. Functionalized polymer chains are linked by lysine ethyl ester diisocyanate to create high molecular weight polyester urethanes. The main objective of this study is to investigate physico-chemical properties, biodegradability in vitro and cytotoxicity. The results showed that the molecular weights of the products reached about 50,000 g/mol and the hydrolytic progress was rapid in the first 2 weeks; the drop in Mn equaled approximately 70%. Tensile strength testing revealed that ductility increased alongside reduced molecular weight of PEG. Cytotoxicity tests carried out according to the EN ISO 10993-5 standard revealed a moderate cytotoxic effect of polymers.

Název v anglickém jazyce

Non-toxic biodegradable polyester urethanes based on PLA

Popis výsledku anglicky

Polylactide (PLA)-based polymers possess indisputable beneficial properties and they are perfectly convenient for temporary medical applications as drug carriers or resorbable supporting devices. Nevertheless, PLA is also known for its rigidity and low mechanical properties.In this research the polyethylene glycol (PEG) of various molecular weight is used for the synthesis of functionalized PLA. Functionalized polymer chains are linked by lysine ethyl ester diisocyanate to create high molecular weight polyester urethanes. The main objective of this study is to investigate physico-chemical properties, biodegradability in vitro and cytotoxicity. The results showed that the molecular weights of the products reached about 50,000 g/mol and the hydrolytic progress was rapid in the first 2 weeks; the drop in Mn equaled approximately 70%. Tensile strength testing revealed that ductility increased alongside reduced molecular weight of PEG. Cytotoxicity tests carried out according to the EN ISO 10993-5 standard revealed a moderate cytotoxic effect of polymers.

Druh

O - Ostatní výsledky

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů