An adamantane-based disubstituted binding motif with picomolar dissociation constants for cucurbit[n]urils in water and related quaternary assemblies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43874881" target="_blank" >RIV/70883521:28610/16:43874881 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28110/16:43874881

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c6ra23524g" target="_blank" >http://dx.doi.org/10.1039/c6ra23524g</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c6ra23524g" target="_blank" >10.1039/c6ra23524g</a>

Jazyk výsledku

angličtina

Název v původním jazyce

An adamantane-based disubstituted binding motif with picomolar dissociation constants for cucurbit[n]urils in water and related quaternary assemblies

Popis výsledku v původním jazyce

A non-axial centerpiece based on 1,3-disubstituted adamantane was designed, and three new guests were prepared. In the structure of the heterotritopic guests, the central adamantane site was combined with two terminal butyl or 1-adamantyl sites. The new central binding motif displayed an extraordinarily high affinity towards CB8'(K-a = (5.3 +/- 0.3) x 10(12) M-1 in water) to allow formation of quaternary assemblies with geometries which are dependent on the nature of macrocycles. Based on the individual binding strengths, the replacement of CB7 by CB8 led to inverse arrangements of the quaternary assemblies; i.e., b-CD is capped at the central site by two CB7 units, while the CB8 prefers the central site to be capped with two b-CD units.

Název v anglickém jazyce

An adamantane-based disubstituted binding motif with picomolar dissociation constants for cucurbit[n]urils in water and related quaternary assemblies

Popis výsledku anglicky

A non-axial centerpiece based on 1,3-disubstituted adamantane was designed, and three new guests were prepared. In the structure of the heterotritopic guests, the central adamantane site was combined with two terminal butyl or 1-adamantyl sites. The new central binding motif displayed an extraordinarily high affinity towards CB8'(K-a = (5.3 +/- 0.3) x 10(12) M-1 in water) to allow formation of quaternary assemblies with geometries which are dependent on the nature of macrocycles. Based on the individual binding strengths, the replacement of CB7 by CB8 led to inverse arrangements of the quaternary assemblies; i.e., b-CD is capped at the central site by two CB7 units, while the CB8 prefers the central site to be capped with two b-CD units.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances: an international journal to further the chemical sciences

ISSN

2046-2069

e-ISSN

—

Svazek periodika

6

Číslo periodika v rámci svazku

107

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

105146-105153

Kód UT WoS článku

000388116500026

EID výsledku v databázi Scopus

2-s2.0-84994515724