The effect of plasma hydrophobization on the realase of Temozolomide from polyester and polylactic acid
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43875546" target="_blank" >RIV/70883521:28610/16:43875546 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The effect of plasma hydrophobization on the realase of Temozolomide from polyester and polylactic acid
Popis výsledku v původním jazyce
In the study, the effect of plasma deposited siloxane coating on the release kinetics of drug Temozolomide (TMZ) from the thin biodegradable polyesters films: polylactic acid (PLA) and polyester urethane (PEU) were investigated. The changes in surface properties were studied by the method of water contact angle measurements, nanoindentation and X-ray photoelectron spectroscopy. The hydrolytic degradation of materials as well as release kinetics of TMZ was investigated by using chromatographic and spectroscopic techniques, respectively. The plasma deposited hydrophobic siloxane coating significantly modified the release kinetics of TMZ from both polymers especially from PLA. The initial burst effect and the release rate of TMZ was significantly reduced. The hydrolytic degradability of materials were slightly reduced after hydrophobization especially for PLA as an effect of wettability modification.
Název v anglickém jazyce
The effect of plasma hydrophobization on the realase of Temozolomide from polyester and polylactic acid
Popis výsledku anglicky
In the study, the effect of plasma deposited siloxane coating on the release kinetics of drug Temozolomide (TMZ) from the thin biodegradable polyesters films: polylactic acid (PLA) and polyester urethane (PEU) were investigated. The changes in surface properties were studied by the method of water contact angle measurements, nanoindentation and X-ray photoelectron spectroscopy. The hydrolytic degradation of materials as well as release kinetics of TMZ was investigated by using chromatographic and spectroscopic techniques, respectively. The plasma deposited hydrophobic siloxane coating significantly modified the release kinetics of TMZ from both polymers especially from PLA. The initial burst effect and the release rate of TMZ was significantly reduced. The hydrolytic degradability of materials were slightly reduced after hydrophobization especially for PLA as an effect of wettability modification.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
CD - Makromolekulární chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.